Role of Oct-4 during acquisition of developmental competence in mouse oocyte

Maurizio Zuccotti; Valeria Merico; Carlo Alberto Redi; Riccardo Bellazzi; James Adjaye; Silvia Garagna

doi:10.1016/S1472-6483(10)60284-2

Role of Oct-4 during acquisition of developmental competence in mouse oocyte

Maurizio Zuccotti, Valeria Merico, Carlo Alberto Redi, Riccardo Bellazzi, James Adjaye, Silvia Garagna

Research output: Contribution to journal › Article › peer-review

Abstract

Knowledge of what determines the developmental competence of oocytes during folliculogenesis is poor. This review, through the analysis of the expression profile of developmentally competent or incompetent mouse oocytes, summarizes the results of recent studies showing that the Oct-4 transcription factor regulating the expression of Stella and Foxj2 at the Nanog locus could play a pivotal role in the establishment of the oocyte's developmental competence.

Original language	English
Pages (from-to)	57-62
Number of pages	6
Journal	Reproductive BioMedicine Online
Volume	19
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/S1472-6483(10)60284-2
Publication status	Published - Dec 2009

Keywords

Developmental competence
Mouse
Oct-4
Oocyte

ASJC Scopus subject areas

Reproductive Medicine
Developmental Biology

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10.1016/S1472-6483(10)60284-2

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AU - Redi, Carlo Alberto

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AU - Adjaye, James

AU - Garagna, Silvia

PY - 2009/12

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AB - Knowledge of what determines the developmental competence of oocytes during folliculogenesis is poor. This review, through the analysis of the expression profile of developmentally competent or incompetent mouse oocytes, summarizes the results of recent studies showing that the Oct-4 transcription factor regulating the expression of Stella and Foxj2 at the Nanog locus could play a pivotal role in the establishment of the oocyte's developmental competence.

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KW - Mouse

KW - Oct-4

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Role of Oct-4 during acquisition of developmental competence in mouse oocyte

Abstract

Keywords

ASJC Scopus subject areas

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