Role of oleic acid in the gut-liver axis: From diet to the regulation of its synthesis via Stearoyl-CoA desaturase 1 (SCD1)

Elena Piccinin, Marica Cariello, Stefania De Santis, Simon Ducheix, Carlo Sabbà, James M. Ntambi, Antonio Moschetta

Research output: Contribution to journalReview articlepeer-review

Abstract

The consumption of an olive oil rich diet has been associated with the diminished incidence of cardiovascular disease and cancer. Several studies have attributed these beneficial effects to oleic acid (C18 n-9), the predominant fatty acid principal component of olive oil. Oleic acid is not an essential fatty acid since it can be endogenously synthesized in humans. Stearoyl-CoA desaturase 1 (SCD1) is the enzyme responsible for oleic acid production and, more generally, for the synthesis of monounsaturated fatty acids (MUFA). The saturated to monounsaturated fatty acid ratio affects the regulation of cell growth and differentiation, and alteration in this ratio has been implicated in a variety of diseases, such as liver dysfunction and intestinal inflammation. In this review, we discuss our current understanding of the impact of gene-nutrient interactions in liver and gut diseases, by taking advantage of the role of SCD1 and its product oleic acid in the modulation of different hepatic and intestinal metabolic pathways.

Original languageEnglish
Article number2283
JournalNutrients
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Gut
  • Liver
  • MUFA
  • Oleic acid
  • Olive oil
  • Stearoyl-CoA desaturase

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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