Role of oxidative stress in experimental sepsis and multisystem organ dysfunction

Ettore Crimi, Vincenzo Sica, Arthur S. Slutsky, Haibo Zhang, Sharon Williams-Ignarro, Louis J. Ignarro, Claudio Napoli

Research output: Contribution to journalArticlepeer-review


Massive increase in radical species can lead to oxidative stress, promoting cell injury and death. This review focuses on experimental evidence of oxidative stress in critical illnesses, sepsis and multisystem organ dysfunction. Oxidative stress could negatively affect organ injury and thus overall survival of experimental models. Based on this experimental evidence, we could improve the rationale of supplementation of antioxidants alone or in combination with standard therapies aimed to reduce oxidative stress as novel adjunct treatment in critical care.

Original languageEnglish
Pages (from-to)665-672
Number of pages8
JournalFree Radical Research
Issue number7
Publication statusPublished - Jul 2006


  • Antioxidants
  • Critical illness
  • Oxidative stress
  • ROS

ASJC Scopus subject areas

  • Biochemistry


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