Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension

Xiang Yang Zhu, Elena Daghini, Alejandro R. Chade, Martin Rodriguez-Porcel, Claudio Napoli, Amir Lerman, Lilach O. Lerman

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE - We tested the hypothesis that in early hypertension (HT), increased oxidative stress leads to myocardial microvascular remodeling. METHODS AND RESULTS - Pigs were studied after a 12-week observation: normal (n=8), untreated renovascular HT (n=8), or HT+chronic antioxidant supplementation (HT+A, n=6). Left ventricular muscle mass (LVMM) and myocardial blood flow (MBF) reserve were determined using electron beam computer tomography (CT), and the spatial density and tortuousity of myocardial microvessels (+, respectively). HT also showed microvascular wall thickening, increased systemic and tissue oxidative stress, inflammation, and expression of vascular endothelial growth factor and its receptor Flk-1, most of which were attenuated by antioxidants. CONCLUSIONS - Myocardial microvascular remodeling in early HT is accompanied by tissue oxidative stress, inflammation, and altered growth factor expression, and attenuated by antioxidant intervention. This study underscores a role of increased oxidative stress in modulating myocardial microvascular architecture in early HT.

Original languageEnglish
Pages (from-to)1746-1752
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Atherosclerosis
  • Hypertension
  • Inflammation
  • Microcirculation
  • Oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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