Role of oxygen free radicals in ischemic and reperfused myocardium

R. Ferrari, C. Ceconi, S. Curello, A. Cargnoni, E. Pasini, F. De Giuli, A. Albertini

Research output: Contribution to journalArticle

Abstract

In recent years there has been considerable interest concerning the role of oxygen radicals in myocardial ischemia and reperfusion injury. The sequential univalent reduction of oxygen gives rise to very reactive intermediate products. Normally, the tissue concentration of these intermediate products of oxygen is limited and the aerobic myocardium survives because of the existence of a delicate balance between the generation of the various oxidants and the maintenance of the antioxidant defense mechanism. Several possible sources have been identified for the production of active oxygen species after ischemia and reperfusion and these sources may be mutually interactive. The ability of scavengers of oxygen free radicals, including vitamin E, to improve mechanical, mitochondrial, and sarcoplasmic reticulum function in animal models of ischemic-reperfusion injury also suggests that oxygen free radicals are partly responsible for myocardial damage in these models, although caution in the interpretation of these data is necessary.

Original languageEnglish
JournalAmerican Journal of Clinical Nutrition
Volume53
Issue number1 SUPPL.
Publication statusPublished - 1991

Fingerprint

myocardium
Free Radicals
Reactive Oxygen Species
Myocardium
oxygen
Reperfusion Injury
sarcoplasmic reticulum
free radical scavengers
Oxygen
myocardial ischemia
ischemia
Myocardial Reperfusion Injury
defense mechanisms
oxidants
vitamin E
reactive oxygen species
Sarcoplasmic Reticulum
antioxidant activity
animal models
Vitamin E

Keywords

  • Myocardial ischemia
  • Myocardial reperfusion
  • Oxygen free radicals
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Ferrari, R., Ceconi, C., Curello, S., Cargnoni, A., Pasini, E., De Giuli, F., & Albertini, A. (1991). Role of oxygen free radicals in ischemic and reperfused myocardium. American Journal of Clinical Nutrition, 53(1 SUPPL.).

Role of oxygen free radicals in ischemic and reperfused myocardium. / Ferrari, R.; Ceconi, C.; Curello, S.; Cargnoni, A.; Pasini, E.; De Giuli, F.; Albertini, A.

In: American Journal of Clinical Nutrition, Vol. 53, No. 1 SUPPL., 1991.

Research output: Contribution to journalArticle

Ferrari, R, Ceconi, C, Curello, S, Cargnoni, A, Pasini, E, De Giuli, F & Albertini, A 1991, 'Role of oxygen free radicals in ischemic and reperfused myocardium', American Journal of Clinical Nutrition, vol. 53, no. 1 SUPPL..
Ferrari R, Ceconi C, Curello S, Cargnoni A, Pasini E, De Giuli F et al. Role of oxygen free radicals in ischemic and reperfused myocardium. American Journal of Clinical Nutrition. 1991;53(1 SUPPL.).
Ferrari, R. ; Ceconi, C. ; Curello, S. ; Cargnoni, A. ; Pasini, E. ; De Giuli, F. ; Albertini, A. / Role of oxygen free radicals in ischemic and reperfused myocardium. In: American Journal of Clinical Nutrition. 1991 ; Vol. 53, No. 1 SUPPL.
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