Role of parity and human papillomavirus in cervical cancer

The IARC multicentric case-control study

Nubia Muñoz, Silvia Franceschi, Cristina Bosetti, Victor Moreno, Rolando Herrero, Jennifer S. Smith, Keerti V. Shah, Chris J L M Meijer, F. Xavier Bosch

Research output: Contribution to journalArticle

370 Citations (Scopus)

Abstract

Background: High parity has long been suspected of being associated with an increased risk of cervical cancer, but previous analyses of this association have not taken the strong effect of human papillomavirus (HPV) into account. To assess the role of reproductive factors in the progression from HPV infection to cancer, we did a pooled analysis including only HPV-positive women. Methods: We pooled data from eight case-control studies on invasive cervical carcinoma (ICC) and two on in-situ carcinoma (ISC) from four continents. 1465 patients with squamous-cell ICCs, 211 with ISCs, 124 with adenocarcinomas or adenosquamous ICCs, and 255 control women, all positive for HPV DNA by PCR-based assays, were analysed. We calculated pooled odds ratios by means of unconditional multiple logistic regression models, and adjusted them for sexual and non-sexual confounding factors. The 95% CI were estimated by treating the odds ratio as floating absolute risk. Findings: We found a direct association between the number of full-term pregnancies and squamous-cell cancer risk: the odds ratio for seven full-term pregnancies or more was 3.8 (95% CI 2.7-5.5) compared with nulliparous women, and 2.3 (1.6-3.2) compared with women who had one or two full-term pregnancies. There was no significant association between risk of adenocarcinoma or adenosquamous carcinoma and number of full-term pregnancies. Interpretation: High parity increases the risk of squamous-cell carcinoma of the cervix among HPV-positive women. A general decline in parity might therefore partly explain the reduction in cervical cancer recently seen in most countries.

Original languageEnglish
Pages (from-to)1093-1101
Number of pages9
JournalLancet
Volume359
Issue number9312
DOIs
Publication statusPublished - Mar 30 2002

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Parity
Uterine Cervical Neoplasms
Case-Control Studies
Odds Ratio
Pregnancy
Adenocarcinoma
Logistic Models
Adenosquamous Carcinoma
Squamous Cell Neoplasms
Papillomavirus Infections
Carcinoma in Situ
Cervix Uteri
Squamous Cell Carcinoma
Epithelial Cells
Carcinoma
Polymerase Chain Reaction
DNA
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Muñoz, N., Franceschi, S., Bosetti, C., Moreno, V., Herrero, R., Smith, J. S., ... Bosch, F. X. (2002). Role of parity and human papillomavirus in cervical cancer: The IARC multicentric case-control study. Lancet, 359(9312), 1093-1101. https://doi.org/10.1016/S0140-6736(02)08151-5

Role of parity and human papillomavirus in cervical cancer : The IARC multicentric case-control study. / Muñoz, Nubia; Franceschi, Silvia; Bosetti, Cristina; Moreno, Victor; Herrero, Rolando; Smith, Jennifer S.; Shah, Keerti V.; Meijer, Chris J L M; Bosch, F. Xavier.

In: Lancet, Vol. 359, No. 9312, 30.03.2002, p. 1093-1101.

Research output: Contribution to journalArticle

Muñoz, N, Franceschi, S, Bosetti, C, Moreno, V, Herrero, R, Smith, JS, Shah, KV, Meijer, CJLM & Bosch, FX 2002, 'Role of parity and human papillomavirus in cervical cancer: The IARC multicentric case-control study', Lancet, vol. 359, no. 9312, pp. 1093-1101. https://doi.org/10.1016/S0140-6736(02)08151-5
Muñoz, Nubia ; Franceschi, Silvia ; Bosetti, Cristina ; Moreno, Victor ; Herrero, Rolando ; Smith, Jennifer S. ; Shah, Keerti V. ; Meijer, Chris J L M ; Bosch, F. Xavier. / Role of parity and human papillomavirus in cervical cancer : The IARC multicentric case-control study. In: Lancet. 2002 ; Vol. 359, No. 9312. pp. 1093-1101.
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