Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer: an observational study

Nicla La Verde, Elena Biagioli, Chiara Gerardi, A. Cordovana, Chiara Casiraghi, Irene Claudia Floriani, Elena Bernardin, G. Farina, Serena Di Cosimo, Maria Chiara Dazzani, Giorgio Gherardi

Research output: Contribution to journalArticle

Abstract

Predicting the risk of sentinel lymph node (SLN) metastasis is important for clinical decision-making in the setting of early breast cancer (EBC). This study is aimed to identify tumor and patient characteristics that influenced the SLN metastatic involvement, with a focus on luminal subtypes. An observational study including women treated for EBC from 2005 to 2013 was conducted. Regression analyses were used to assess the association between SLN metastasis and age, menopausal status, tumor size, histological grading, presence of extensive “in situ” carcinoma components, lymphovascular invasion (LVI), and expression of Ki-67, hormone receptors, and HER2. Of 345 women, 84 (24.3 %) had at least one SLN metastasis; 63.1 % were macrometastases. Among all patients, 31.6 % exhibited LVI. In univariate analyses, tumor size, histological grade, and LVI were associated with SLN metastasis. The multivariate model confirmed only the association between LVI and SLN status (OR 3.27, 95 % CI 1.85–5.68; p

Original languageEnglish
Article number114
Pages (from-to)1-9
Number of pages9
JournalSpringerPlus
Volume5
Issue number1
DOIs
Publication statusPublished - Dec 1 2016

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Observational Studies
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Carcinoma in Situ
Sentinel Lymph Node
Regression Analysis
Hormones

ASJC Scopus subject areas

  • General

Cite this

Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer : an observational study. / La Verde, Nicla; Biagioli, Elena; Gerardi, Chiara; Cordovana, A.; Casiraghi, Chiara; Floriani, Irene Claudia; Bernardin, Elena; Farina, G.; Di Cosimo, Serena; Dazzani, Maria Chiara; Gherardi, Giorgio.

In: SpringerPlus, Vol. 5, No. 1, 114, 01.12.2016, p. 1-9.

Research output: Contribution to journalArticle

La Verde, N, Biagioli, E, Gerardi, C, Cordovana, A, Casiraghi, C, Floriani, IC, Bernardin, E, Farina, G, Di Cosimo, S, Dazzani, MC & Gherardi, G 2016, 'Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer: an observational study', SpringerPlus, vol. 5, no. 1, 114, pp. 1-9. https://doi.org/10.1186/s40064-016-1720-9
La Verde, Nicla ; Biagioli, Elena ; Gerardi, Chiara ; Cordovana, A. ; Casiraghi, Chiara ; Floriani, Irene Claudia ; Bernardin, Elena ; Farina, G. ; Di Cosimo, Serena ; Dazzani, Maria Chiara ; Gherardi, Giorgio. / Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer : an observational study. In: SpringerPlus. 2016 ; Vol. 5, No. 1. pp. 1-9.
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