Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients: Results From a Large Prospective Multicenter European Study

Giorgio Bozzini, Marco Provenzano, Javier Romero Otero, Markus Margreiter, Eduardo Garcia Cruz, Boris Osmolorskij, Paolo Verze, Nicola Pavan, Francesco Sanguedolce, Nicolo Maria Buffi, Guazzoni Giorgio Ferrucio, Gianluigi Taverna

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective To determine the role of penile Doppler ultrasound (PDU) compared with magnetic resonance imaging (MRI) in preoperative diagnostic evaluation of patients with penile squamous cell carcinoma. Materials and Methods A prospective analysis on patients presenting with clinical diagnosis of penile squamous cell carcinoma from 6 different European hospitals between 2012 and 2014 was carried out. Each patient who had planned an organ sparing approach underwent an MRI and PDU both with an artificial erection with prostaglandin E 1. Age, evidence of MRI or PDU corpora cavernosa infiltration, frozen section examination report, definitive pathological report, and surgical approach used per patient were recorded. Accuracy, precision, negative predictive value, sensitivity, and specificity were calculated. Outcomes were statistically evaluated. Results Two hundred patients were enrolled in the study. The mean age of the patients was 67.35 ± 15.45 (range 51-82). All of the patients were treated surgically. Of the 200 patients, 135 (67.5%) underwent a corpora sparing approach, whereas 65 had a partial penectomy because of the frozen section outcome. About corpora cavernosa infiltration, the definitive outcome confirmed the frozen section examination. PDU vs MRI accuracy was 96.5% vs 90.5%; precision was 92.6% vs 96%; sensitivity was 96.9% vs 73.8%, specificity was 96.2% vs 98.5%. Despite sensitivity (P 

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalUrology
Volume90
DOIs
Publication statusPublished - Apr 1 2016

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Multicenter Studies
Squamous Cell Carcinoma
Doppler Ultrasonography
Frozen Sections
Magnetic Resonance Imaging
Prostaglandins E
Sensitivity and Specificity

ASJC Scopus subject areas

  • Urology

Cite this

Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients : Results From a Large Prospective Multicenter European Study. / Bozzini, Giorgio; Provenzano, Marco; Romero Otero, Javier; Margreiter, Markus; Garcia Cruz, Eduardo; Osmolorskij, Boris; Verze, Paolo; Pavan, Nicola; Sanguedolce, Francesco; Buffi, Nicolo Maria; Ferrucio, Guazzoni Giorgio; Taverna, Gianluigi.

In: Urology, Vol. 90, 01.04.2016, p. 131-135.

Research output: Contribution to journalArticle

Bozzini, G, Provenzano, M, Romero Otero, J, Margreiter, M, Garcia Cruz, E, Osmolorskij, B, Verze, P, Pavan, N, Sanguedolce, F, Buffi, NM, Ferrucio, GG & Taverna, G 2016, 'Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients: Results From a Large Prospective Multicenter European Study', Urology, vol. 90, pp. 131-135. https://doi.org/10.1016/j.urology.2016.01.003
Bozzini, Giorgio ; Provenzano, Marco ; Romero Otero, Javier ; Margreiter, Markus ; Garcia Cruz, Eduardo ; Osmolorskij, Boris ; Verze, Paolo ; Pavan, Nicola ; Sanguedolce, Francesco ; Buffi, Nicolo Maria ; Ferrucio, Guazzoni Giorgio ; Taverna, Gianluigi. / Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients : Results From a Large Prospective Multicenter European Study. In: Urology. 2016 ; Vol. 90. pp. 131-135.
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abstract = "Objective To determine the role of penile Doppler ultrasound (PDU) compared with magnetic resonance imaging (MRI) in preoperative diagnostic evaluation of patients with penile squamous cell carcinoma. Materials and Methods A prospective analysis on patients presenting with clinical diagnosis of penile squamous cell carcinoma from 6 different European hospitals between 2012 and 2014 was carried out. Each patient who had planned an organ sparing approach underwent an MRI and PDU both with an artificial erection with prostaglandin E 1. Age, evidence of MRI or PDU corpora cavernosa infiltration, frozen section examination report, definitive pathological report, and surgical approach used per patient were recorded. Accuracy, precision, negative predictive value, sensitivity, and specificity were calculated. Outcomes were statistically evaluated. Results Two hundred patients were enrolled in the study. The mean age of the patients was 67.35 ± 15.45 (range 51-82). All of the patients were treated surgically. Of the 200 patients, 135 (67.5{\%}) underwent a corpora sparing approach, whereas 65 had a partial penectomy because of the frozen section outcome. About corpora cavernosa infiltration, the definitive outcome confirmed the frozen section examination. PDU vs MRI accuracy was 96.5{\%} vs 90.5{\%}; precision was 92.6{\%} vs 96{\%}; sensitivity was 96.9{\%} vs 73.8{\%}, specificity was 96.2{\%} vs 98.5{\%}. Despite sensitivity (P ",
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AU - Romero Otero, Javier

AU - Margreiter, Markus

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AU - Osmolorskij, Boris

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N2 - Objective To determine the role of penile Doppler ultrasound (PDU) compared with magnetic resonance imaging (MRI) in preoperative diagnostic evaluation of patients with penile squamous cell carcinoma. Materials and Methods A prospective analysis on patients presenting with clinical diagnosis of penile squamous cell carcinoma from 6 different European hospitals between 2012 and 2014 was carried out. Each patient who had planned an organ sparing approach underwent an MRI and PDU both with an artificial erection with prostaglandin E 1. Age, evidence of MRI or PDU corpora cavernosa infiltration, frozen section examination report, definitive pathological report, and surgical approach used per patient were recorded. Accuracy, precision, negative predictive value, sensitivity, and specificity were calculated. Outcomes were statistically evaluated. Results Two hundred patients were enrolled in the study. The mean age of the patients was 67.35 ± 15.45 (range 51-82). All of the patients were treated surgically. Of the 200 patients, 135 (67.5%) underwent a corpora sparing approach, whereas 65 had a partial penectomy because of the frozen section outcome. About corpora cavernosa infiltration, the definitive outcome confirmed the frozen section examination. PDU vs MRI accuracy was 96.5% vs 90.5%; precision was 92.6% vs 96%; sensitivity was 96.9% vs 73.8%, specificity was 96.2% vs 98.5%. Despite sensitivity (P 

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