Ruolo dell'imaging pesato in perfusione a 3 Tesla nella valutazione del grado di malignità dei gliomi cerebrali

Translated title of the contribution: Role of perfusion-weighted imaging at 3 Tesla in the assessment of malignancy of cerebral gliomas

A. Di Costanzo, S. Pollice, F. Trojsi, G. M. Giannatempo, T. Popolizio, L. Canalis, M. Armillotta, A. Maggialetti, A. Carriero, G. Tedeschi, T. Scarabino

Research output: Contribution to journalArticle

Abstract

Purpose. This study was performed to clarify the role of perfusion-weighted imaging (PWI) at 3 Tesla in the characterisation of haemodynamic heterogeneity within gliomas and surrounding tissues and in the differentiation of high-grade from low-grade gliomas. Materials and methods. We examined 36 patients with histologically verified gliomas (25 with high-grade and 11 with low-grade gliomas). PWI was performed by first-pass gadopentetate dimeglumine T2*-weighted echo-planar images, and cerebral blood volume (CBV) maps were computed with a nondiffusible tracer model. Relative CBV (rCBV) was calculated by dividing CBV in pathological areas by that in contralateral white matter. Results. In high-grade gliomas, rCBV were markedly increased in mass [mean±standard deviation (SD), 4.3±1.2] and margins (4.0±1.1) and reduced in necrotic areas (0.3±0.3). Oedematous-appearing areas were divided in two groups according to signal intensity on T2-weighted images: tumour with lower (nearly isointense to grey matter) and oedema with higher (scarcely isointense to cerebrospinal fluid) signal intensity. Tumour showed significantly higher rCBV than did oedema (1.8±0.5 vs. 0.5±0.2; p

Translated title of the contributionRole of perfusion-weighted imaging at 3 Tesla in the assessment of malignancy of cerebral gliomas
Original languageItalian
Pages (from-to)134-143
Number of pages10
JournalRadiologia Medica
Volume113
Issue number1
DOIs
Publication statusPublished - Feb 2008

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Di Costanzo, A., Pollice, S., Trojsi, F., Giannatempo, G. M., Popolizio, T., Canalis, L., Armillotta, M., Maggialetti, A., Carriero, A., Tedeschi, G., & Scarabino, T. (2008). Ruolo dell'imaging pesato in perfusione a 3 Tesla nella valutazione del grado di malignità dei gliomi cerebrali. Radiologia Medica, 113(1), 134-143. https://doi.org/10.1007/s11547-008-0232-2