Role of peroxisome proliferator-activated receptor γ and its ligands in the control of immune responses

Alessio Nencioni, Sebastian Wesselborg, Peter Brossart

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

To ensure that efficient immune responses against dangerous antigens are raised while tolerance to self molecules is preserved, the immune system tightly regulates activation and survival of its cellular compartments through mechanisms only partially characterized. In this context, recent evidence indicates a role in immunity of the nuclear receptor PPAR-γ, which is upregulated in activated lymphocytes and in dendritic cells. Preliminary in vitro studies indicate that PPAR-γ activation profoundly alters the immune properties of these cells, usually leading to the inhibition of immune responses. Naturally occurring PPAR-γ ligands include the cyclopentenone prostaglandins of the J series, which are present in bone marrow, thymus, and secondary lymphatic tissues. The levels of these metabolites are increased in inflamed tissues, where they exert strong anti-inflammatory effects leading to resolution of inflammation and wound healing. Cyclopentenone prostaglandins activate both PPAR-γ-dependent and PPAR-γ-independent pathways, possess intrinsic proapoptotic potential and are direct inhibitors of NF-κB signaling. The relevance of these effects in vivo still awaits proper evaluation in humans. Some of the newly described regulatory pathways might eventually be exploited in the treatment of immune diseases by means of PPAR-γ ligands, such as thiazolidinediones or prostaglandins.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalCritical Reviews in Immunology
Volume23
Issue number1-2
DOIs
Publication statusPublished - 2003

Fingerprint

Peroxisome Proliferator-Activated Receptors
Ligands
Prostaglandins
Thiazolidinediones
Immune System Diseases
Lymphoid Tissue
Cytoplasmic and Nuclear Receptors
Wound Healing
Dendritic Cells
Thymus Gland
Immune System
Immunity
Anti-Inflammatory Agents
Bone Marrow
Lymphocytes
Inflammation
Antigens
Survival

Keywords

  • Apoptosis
  • Cyclopentenone prostaglandins
  • Dendritic cells
  • Lymphocytes
  • Tolerance

ASJC Scopus subject areas

  • Immunology

Cite this

Role of peroxisome proliferator-activated receptor γ and its ligands in the control of immune responses. / Nencioni, Alessio; Wesselborg, Sebastian; Brossart, Peter.

In: Critical Reviews in Immunology, Vol. 23, No. 1-2, 2003, p. 1-13.

Research output: Contribution to journalArticle

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