Role of pH on stability and mechanical properties of gelatin films

Michela Gioffrè, Paola Torricelli, Silvia Panzavolta, Katia Rubini, Adriana Bigi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the film-forming solution pH on the triple-helix content, thermal stability, and mechanical properties of gelatin films was investigated. The films were prepared from solutions at different pHs of type A pigskin gelatin, and their mechanical characteristics were determined. At pHs higher than 9 and lower than 5, Young's modulus, E, and the stress at break, σ b, of the films decreased significantly. Cross-linking with genipin reduced deformation at break, ε b, and increased Young's modulus. The intensity of the 1.1-nm X-ray diffraction reflection and the denaturation enthalpy decreased at these pHs, indicating that the triple helix reduced. Preliminary in vitro tests on the cross-linked samples indicated good cell proliferation and viability.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalJournal of Bioactive and Compatible Polymers
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • DSC
  • gelatin films
  • genipin cross-linking
  • mechanical properties
  • pH
  • triple-helix content
  • XRD

ASJC Scopus subject areas

  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry
  • Bioengineering

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