Role of plaque calcification regulators osteoprotegerin and matrix Gla-proteins in stable angina and acute myocardial infarction

Alberto Margonato, Riccardo Gorla, Andrea Macchi, Fabio Buzzetti, Irene Franzoni, Maria Cristina Pedrigi, Isabella Rosa, Marcella Sirtori, Isabella Villa, Alessandro Rubinacci

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To assess serum levels of the plaque calcification regulators osteoprotegerin (OPG) and Matrix Gla-proteins (MGP) in individuals with stable angina and acute myocardial infarction submitted to coronary angiography and their relation to coronary artery disease burden. Methods: The study included 40 individuals affected by ST-elevation myocardial infarction (STEMI) and 40 individuals with stable angina who all underwent coronary angiography, with evaluation of the extent of coronary artery disease by Syntax Score calculation and measurement of serum OPG and MGP levels. Osteoporosis was excluded by femoral and vertebral computerized bone mineralometry. Results: Serum OPG and MGP levels were respectively 3.87±1.07 pmol/l and 6.80±2.43 nmol/l in the stable angina group, 7.57±1.5 pmol/l and 7.18±1.93 nmol/l in the STEMI group (P

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalJournal of Cardiovascular Medicine
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Keywords

  • Coronary artery disease
  • Matrix Gla-proteins
  • Osteoprotegerin
  • Plaque calcification
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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