TY - JOUR
T1 - Role of plaque calcification regulators osteoprotegerin and matrix Gla-proteins in stable angina and acute myocardial infarction
AU - Margonato, Alberto
AU - Gorla, Riccardo
AU - Macchi, Andrea
AU - Buzzetti, Fabio
AU - Franzoni, Irene
AU - Pedrigi, Maria Cristina
AU - Rosa, Isabella
AU - Sirtori, Marcella
AU - Villa, Isabella
AU - Rubinacci, Alessandro
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Aim: To assess serum levels of the plaque calcification regulators osteoprotegerin (OPG) and Matrix Gla-proteins (MGP) in individuals with stable angina and acute myocardial infarction submitted to coronary angiography and their relation to coronary artery disease burden. Methods: The study included 40 individuals affected by ST-elevation myocardial infarction (STEMI) and 40 individuals with stable angina who all underwent coronary angiography, with evaluation of the extent of coronary artery disease by Syntax Score calculation and measurement of serum OPG and MGP levels. Osteoporosis was excluded by femoral and vertebral computerized bone mineralometry. Results: Serum OPG and MGP levels were respectively 3.87±1.07 pmol/l and 6.80±2.43 nmol/l in the stable angina group, 7.57±1.5 pmol/l and 7.18±1.93 nmol/l in the STEMI group (P
AB - Aim: To assess serum levels of the plaque calcification regulators osteoprotegerin (OPG) and Matrix Gla-proteins (MGP) in individuals with stable angina and acute myocardial infarction submitted to coronary angiography and their relation to coronary artery disease burden. Methods: The study included 40 individuals affected by ST-elevation myocardial infarction (STEMI) and 40 individuals with stable angina who all underwent coronary angiography, with evaluation of the extent of coronary artery disease by Syntax Score calculation and measurement of serum OPG and MGP levels. Osteoporosis was excluded by femoral and vertebral computerized bone mineralometry. Results: Serum OPG and MGP levels were respectively 3.87±1.07 pmol/l and 6.80±2.43 nmol/l in the stable angina group, 7.57±1.5 pmol/l and 7.18±1.93 nmol/l in the STEMI group (P
KW - Coronary artery disease
KW - Matrix Gla-proteins
KW - Osteoprotegerin
KW - Plaque calcification
KW - ST-elevation myocardial infarction
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U2 - 10.2459/JCM.0b013e328365b57d
DO - 10.2459/JCM.0b013e328365b57d
M3 - Article
C2 - 24566391
AN - SCOPUS:84925881573
VL - 16
SP - 156
EP - 162
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 3
ER -