Role of postoperative radiotherapy after pelvic lymphadenectomy and radical retropubic prostatectomy: A single institute experience of 415 patients

Cesare Cozzarini; Angelo Bolognesi; Giovanni Luca Ceresoli; Claudio Fiorino; Alberto Rossa; Roberto Bertini; Renzo Colombo; Luigi Da Pozzo; Francesco Montorsi; Marco Roscigno; Riccardo Calandrino; Patrizio Rigatti; Eugenio Villa

doi:10.1016/j.ijrobp.2003.12.001

Role of postoperative radiotherapy after pelvic lymphadenectomy and radical retropubic prostatectomy: A single institute experience of 415 patients

Cesare Cozzarini, Angelo Bolognesi, Giovanni Luca Ceresoli, Claudio Fiorino, Alberto Rossa, Roberto Bertini, Renzo Colombo, Luigi Da Pozzo, Francesco Montorsi, Marco Roscigno, Riccardo Calandrino, Patrizio Rigatti, Eugenio Villa

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose To evaluate the clinical benefit deriving from early (within 6 months) radiotherapy (ERT) after pelvic lymphadenectomy and radical retropubic prostatectomy for localized/locally advanced adenocarcinoma of the prostate in a single-institution series. Methods and materials We retrospectively analyzed 415 patients who underwent pelvic lymphadenectomy and radical retropubic prostatectomy between 1986 and 1998 for pT2b-pT4, pN0-pN1 prostate carcinoma. Of the 415 patients, 237 underwent ERT for adverse pathologic findings and 178 patients did not receive RT or underwent salvage RT ≤6 months (salvage or no RT [SNRT]). Results After a median follow-up of 62 months, the 8-year actuarial freedom from biochemical, local and systemic failure, and cause-specific survival rate was 69% vs. 31% (p

Original language	English
Pages (from-to)	674-683
Number of pages	10
Journal	International Journal of Radiation Oncology Biology Physics
Volume	59
Issue number	3
DOIs	https://doi.org/10.1016/j.ijrobp.2003.12.001
Publication status	Published - Jul 1 2004

Keywords

Adjuvant radiotherapy
Prostatectomy
Prostatic neoplasms

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Radiation

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Cozzarini, C., Bolognesi, A., Ceresoli, G. L., Fiorino, C., Rossa, A., Bertini, R., Colombo, R., Da Pozzo, L., Montorsi, F., Roscigno, M., Calandrino, R., Rigatti, P., & Villa, E. (2004). Role of postoperative radiotherapy after pelvic lymphadenectomy and radical retropubic prostatectomy: A single institute experience of 415 patients. International Journal of Radiation Oncology Biology Physics, 59(3), 674-683. https://doi.org/10.1016/j.ijrobp.2003.12.001

Role of postoperative radiotherapy after pelvic lymphadenectomy and radical retropubic prostatectomy : A single institute experience of 415 patients. / Cozzarini, Cesare; Bolognesi, Angelo; Ceresoli, Giovanni Luca; Fiorino, Claudio; Rossa, Alberto; Bertini, Roberto ; Colombo, Renzo; Da Pozzo, Luigi; Montorsi, Francesco; Roscigno, Marco; Calandrino, Riccardo; Rigatti, Patrizio; Villa, Eugenio.

In: International Journal of Radiation Oncology Biology Physics, Vol. 59, No. 3, 01.07.2004, p. 674-683.

Research output: Contribution to journal › Article › peer-review

Cozzarini, C, Bolognesi, A, Ceresoli, GL, Fiorino, C, Rossa, A, Bertini, R , Colombo, R, Da Pozzo, L, Montorsi, F, Roscigno, M, Calandrino, R, Rigatti, P & Villa, E 2004, 'Role of postoperative radiotherapy after pelvic lymphadenectomy and radical retropubic prostatectomy: A single institute experience of 415 patients', International Journal of Radiation Oncology Biology Physics, vol. 59, no. 3, pp. 674-683. https://doi.org/10.1016/j.ijrobp.2003.12.001

Cozzarini, Cesare ; Bolognesi, Angelo ; Ceresoli, Giovanni Luca ; Fiorino, Claudio ; Rossa, Alberto ; Bertini, Roberto ; Colombo, Renzo ; Da Pozzo, Luigi ; Montorsi, Francesco ; Roscigno, Marco ; Calandrino, Riccardo ; Rigatti, Patrizio ; Villa, Eugenio. / Role of postoperative radiotherapy after pelvic lymphadenectomy and radical retropubic prostatectomy : A single institute experience of 415 patients. In: International Journal of Radiation Oncology Biology Physics. 2004 ; Vol. 59, No. 3. pp. 674-683.

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abstract = "Purpose To evaluate the clinical benefit deriving from early (within 6 months) radiotherapy (ERT) after pelvic lymphadenectomy and radical retropubic prostatectomy for localized/locally advanced adenocarcinoma of the prostate in a single-institution series. Methods and materials We retrospectively analyzed 415 patients who underwent pelvic lymphadenectomy and radical retropubic prostatectomy between 1986 and 1998 for pT2b-pT4, pN0-pN1 prostate carcinoma. Of the 415 patients, 237 underwent ERT for adverse pathologic findings and 178 patients did not receive RT or underwent salvage RT ≤6 months (salvage or no RT [SNRT]). Results After a median follow-up of 62 months, the 8-year actuarial freedom from biochemical, local and systemic failure, and cause-specific survival rate was 69% vs. 31% (p ",

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AU - Fiorino, Claudio

AU - Rossa, Alberto

AU - Bertini, Roberto

AU - Colombo, Renzo

AU - Da Pozzo, Luigi

AU - Montorsi, Francesco

AU - Roscigno, Marco

AU - Calandrino, Riccardo

AU - Rigatti, Patrizio

AU - Villa, Eugenio

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AB - Purpose To evaluate the clinical benefit deriving from early (within 6 months) radiotherapy (ERT) after pelvic lymphadenectomy and radical retropubic prostatectomy for localized/locally advanced adenocarcinoma of the prostate in a single-institution series. Methods and materials We retrospectively analyzed 415 patients who underwent pelvic lymphadenectomy and radical retropubic prostatectomy between 1986 and 1998 for pT2b-pT4, pN0-pN1 prostate carcinoma. Of the 415 patients, 237 underwent ERT for adverse pathologic findings and 178 patients did not receive RT or underwent salvage RT ≤6 months (salvage or no RT [SNRT]). Results After a median follow-up of 62 months, the 8-year actuarial freedom from biochemical, local and systemic failure, and cause-specific survival rate was 69% vs. 31% (p

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