Role of pre-emptive analgesia in reduction mammaplasty

P. Di Marco, F. R. Grippaudo, G. Della Rocca, R. De Vita

Research output: Contribution to journalArticlepeer-review


Pre-emptive analgesia is an antinociceptive treatment that prevents altered central excitability from high intensity noxious stimuli. The aim of this study was to evaluate the efficacy of pre-emptive analgesia in patients due to have elective breast reduction that usually requires drugs for postoperative pain control. Sixty women, ASA grades I-II, were randomly divided into two groups: 30 patients were given ropivacaine infiltration 1.5 mg/ml plus adrenaline 1/200 000 in normal saline 100 ml before the skin incision, and 30 had normal saline 100 ml plus adrenaline 1/200 000 infiltrated. Postoperative pain was evaluated by an observer who was unaware of the treatment given, and scored on a visual analogue score (VAS) during the first 72 hours postoperatively. Analgesic requirements were recorded. There was a statistically significant difference between groups in the amount of additional pain control required during the early postoperative period, which suggests that pre-emptive analgesia reduces pain after reduction mammaplasty.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Issue number3
Publication statusPublished - 2001


  • Postoperative pain
  • Pre-emptive analgesia
  • Reduction mammaplasty
  • Ropivacaine
  • VAS

ASJC Scopus subject areas

  • Surgery

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