Role of prostaglandins in captopril-induced natriuresis.

G. Conte, A. Dal Canton, G. Maglionico, C. Di Spigno, B. Pirone, D. Russo, G. Di Minno, V. E. Andreucci

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To determine whether prostaglandins (PG) contribute to captopril-induced natriuresis, 20 hypertensive subjects were assigned to one of the following three groups: group a, captopril (C) administration; group b, C + indomethacin (I); group c, I alone. Captopril was given in a dose of 100, 200, 400 mg/day and indomethacin in a dose of 100mg/day for one week. In group a (n = 10), natriuresis was clearly increased in the seven day periods with captopril in a dose of 200 and 400mg/day but not at 100mg/day. After captopril 200 or 400mg/day, but not 100mg/day, urinary PGE2 and PGI2 excretion significantly increased while filtration fraction fell due to a rise in renal plasma flow. Plasma aldosterone (PA) significantly decreased after C(p less than 0.05). In group b (n = 7), natriuresis disappeared during captopril 200 or 400mg/day and indomethacin administration even when PA decreased as in group a. In group c (n = 3), natriuresis was unchanged. In conclusion, natriuresis by C is critically dependent upon increased secretion of PG.

Fingerprint

Natriuresis
Captopril
Prostaglandins
Indomethacin
Aldosterone
Renal Plasma Flow
Epoprostenol
Dinoprostone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Role of prostaglandins in captopril-induced natriuresis. / Conte, G.; Dal Canton, A.; Maglionico, G.; Di Spigno, C.; Pirone, B.; Russo, D.; Di Minno, G.; Andreucci, V. E.

In: Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress, Vol. 21, 1985, p. 820-824.

Research output: Contribution to journalArticle

Conte, G. ; Dal Canton, A. ; Maglionico, G. ; Di Spigno, C. ; Pirone, B. ; Russo, D. ; Di Minno, G. ; Andreucci, V. E. / Role of prostaglandins in captopril-induced natriuresis. In: Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress. 1985 ; Vol. 21. pp. 820-824.
@article{202c3e84d166477f92cad023bfe62c89,
title = "Role of prostaglandins in captopril-induced natriuresis.",
abstract = "To determine whether prostaglandins (PG) contribute to captopril-induced natriuresis, 20 hypertensive subjects were assigned to one of the following three groups: group a, captopril (C) administration; group b, C + indomethacin (I); group c, I alone. Captopril was given in a dose of 100, 200, 400 mg/day and indomethacin in a dose of 100mg/day for one week. In group a (n = 10), natriuresis was clearly increased in the seven day periods with captopril in a dose of 200 and 400mg/day but not at 100mg/day. After captopril 200 or 400mg/day, but not 100mg/day, urinary PGE2 and PGI2 excretion significantly increased while filtration fraction fell due to a rise in renal plasma flow. Plasma aldosterone (PA) significantly decreased after C(p less than 0.05). In group b (n = 7), natriuresis disappeared during captopril 200 or 400mg/day and indomethacin administration even when PA decreased as in group a. In group c (n = 3), natriuresis was unchanged. In conclusion, natriuresis by C is critically dependent upon increased secretion of PG.",
author = "G. Conte and {Dal Canton}, A. and G. Maglionico and {Di Spigno}, C. and B. Pirone and D. Russo and {Di Minno}, G. and Andreucci, {V. E.}",
year = "1985",
language = "English",
volume = "21",
pages = "820--824",
journal = "Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress",
issn = "0308-9401",

}

TY - JOUR

T1 - Role of prostaglandins in captopril-induced natriuresis.

AU - Conte, G.

AU - Dal Canton, A.

AU - Maglionico, G.

AU - Di Spigno, C.

AU - Pirone, B.

AU - Russo, D.

AU - Di Minno, G.

AU - Andreucci, V. E.

PY - 1985

Y1 - 1985

N2 - To determine whether prostaglandins (PG) contribute to captopril-induced natriuresis, 20 hypertensive subjects were assigned to one of the following three groups: group a, captopril (C) administration; group b, C + indomethacin (I); group c, I alone. Captopril was given in a dose of 100, 200, 400 mg/day and indomethacin in a dose of 100mg/day for one week. In group a (n = 10), natriuresis was clearly increased in the seven day periods with captopril in a dose of 200 and 400mg/day but not at 100mg/day. After captopril 200 or 400mg/day, but not 100mg/day, urinary PGE2 and PGI2 excretion significantly increased while filtration fraction fell due to a rise in renal plasma flow. Plasma aldosterone (PA) significantly decreased after C(p less than 0.05). In group b (n = 7), natriuresis disappeared during captopril 200 or 400mg/day and indomethacin administration even when PA decreased as in group a. In group c (n = 3), natriuresis was unchanged. In conclusion, natriuresis by C is critically dependent upon increased secretion of PG.

AB - To determine whether prostaglandins (PG) contribute to captopril-induced natriuresis, 20 hypertensive subjects were assigned to one of the following three groups: group a, captopril (C) administration; group b, C + indomethacin (I); group c, I alone. Captopril was given in a dose of 100, 200, 400 mg/day and indomethacin in a dose of 100mg/day for one week. In group a (n = 10), natriuresis was clearly increased in the seven day periods with captopril in a dose of 200 and 400mg/day but not at 100mg/day. After captopril 200 or 400mg/day, but not 100mg/day, urinary PGE2 and PGI2 excretion significantly increased while filtration fraction fell due to a rise in renal plasma flow. Plasma aldosterone (PA) significantly decreased after C(p less than 0.05). In group b (n = 7), natriuresis disappeared during captopril 200 or 400mg/day and indomethacin administration even when PA decreased as in group a. In group c (n = 3), natriuresis was unchanged. In conclusion, natriuresis by C is critically dependent upon increased secretion of PG.

UR - http://www.scopus.com/inward/record.url?scp=0021973655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021973655&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 820

EP - 824

JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

JF - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

SN - 0308-9401

ER -