Abstract
To determine whether prostaglandins (PG) contribute to captopril-induced natriuresis, 20 hypertensive subjects were assigned to one of the following three groups: group a, captopril (C) administration; group b, C + indomethacin (I); group c, I alone. Captopril was given in a dose of 100, 200, 400 mg/day and indomethacin in a dose of 100mg/day for one week. In group a (n = 10), natriuresis was clearly increased in the seven day periods with captopril in a dose of 200 and 400mg/day but not at 100mg/day. After captopril 200 or 400mg/day, but not 100mg/day, urinary PGE2 and PGI2 excretion significantly increased while filtration fraction fell due to a rise in renal plasma flow. Plasma aldosterone (PA) significantly decreased after C(p less than 0.05). In group b (n = 7), natriuresis disappeared during captopril 200 or 400mg/day and indomethacin administration even when PA decreased as in group a. In group c (n = 3), natriuresis was unchanged. In conclusion, natriuresis by C is critically dependent upon increased secretion of PG.
| Original language | English |
|---|---|
| Pages (from-to) | 820-824 |
| Number of pages | 5 |
| Journal | Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress |
| Volume | 21 |
| Publication status | Published - 1985 |
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- Medicine(all)
Cite this
Role of prostaglandins in captopril-induced natriuresis. / Conte, G.; Dal Canton, A.; Maglionico, G.; Di Spigno, C.; Pirone, B.; Russo, D.; Di Minno, G.; Andreucci, V. E.
In: Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress, Vol. 21, 1985, p. 820-824.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of prostaglandins in captopril-induced natriuresis.
AU - Conte, G.
AU - Dal Canton, A.
AU - Maglionico, G.
AU - Di Spigno, C.
AU - Pirone, B.
AU - Russo, D.
AU - Di Minno, G.
AU - Andreucci, V. E.
PY - 1985
Y1 - 1985
N2 - To determine whether prostaglandins (PG) contribute to captopril-induced natriuresis, 20 hypertensive subjects were assigned to one of the following three groups: group a, captopril (C) administration; group b, C + indomethacin (I); group c, I alone. Captopril was given in a dose of 100, 200, 400 mg/day and indomethacin in a dose of 100mg/day for one week. In group a (n = 10), natriuresis was clearly increased in the seven day periods with captopril in a dose of 200 and 400mg/day but not at 100mg/day. After captopril 200 or 400mg/day, but not 100mg/day, urinary PGE2 and PGI2 excretion significantly increased while filtration fraction fell due to a rise in renal plasma flow. Plasma aldosterone (PA) significantly decreased after C(p less than 0.05). In group b (n = 7), natriuresis disappeared during captopril 200 or 400mg/day and indomethacin administration even when PA decreased as in group a. In group c (n = 3), natriuresis was unchanged. In conclusion, natriuresis by C is critically dependent upon increased secretion of PG.
AB - To determine whether prostaglandins (PG) contribute to captopril-induced natriuresis, 20 hypertensive subjects were assigned to one of the following three groups: group a, captopril (C) administration; group b, C + indomethacin (I); group c, I alone. Captopril was given in a dose of 100, 200, 400 mg/day and indomethacin in a dose of 100mg/day for one week. In group a (n = 10), natriuresis was clearly increased in the seven day periods with captopril in a dose of 200 and 400mg/day but not at 100mg/day. After captopril 200 or 400mg/day, but not 100mg/day, urinary PGE2 and PGI2 excretion significantly increased while filtration fraction fell due to a rise in renal plasma flow. Plasma aldosterone (PA) significantly decreased after C(p less than 0.05). In group b (n = 7), natriuresis disappeared during captopril 200 or 400mg/day and indomethacin administration even when PA decreased as in group a. In group c (n = 3), natriuresis was unchanged. In conclusion, natriuresis by C is critically dependent upon increased secretion of PG.
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M3 - Article
VL - 21
SP - 820
EP - 824
JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
JF - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
SN - 0308-9401
ER -