Role of pulmonary venous flow velocity indexes in the clinical assessment of patients with hypertrophic cardiomyopathy

Camillo Autore, Maria T. Mallus, Carmine D. Vizza, Marco Piccininno, Monica Castaldo, Domenico Cartoni, Francesco Fedele, Armando Dagianti

Research output: Contribution to journalArticle

Abstract

Doppler indexes of transmitral flow velocity (FV) have been used for assessment of diastolic performance in hypertrophic cardiomyopathy (HCM). These indexes, however, are importantly influenced by filling pressure and load. Measurements of reverse pulmonary flow at atrial contraction (RPFA) reflect left ventricular (LV) distensibility and could permit a more accurate evaluation of diastolic performance in HCM. Both transmitral FV and RPFA indexes were obtained in 45 pts with HCM (mean age 38±16 yr.; 69% male); 36 were in NYHA class I-II and 9 in class III. Obstruction to LV outflow was present in 16 pts. Measurements were compared to those obtained in 43 normal subjects matched for age and sex (mean age 38±15 yr.; 69% male). Patients controls p<% abnormal A (cm/s) 50±17 43±9 0.05 22 E/A 1.3±0.6 1.8±0.6 0.005 7 DT (ms) 191±63 159±25 0.005 36 RPFA(cm/s) 36±10 24±5 0.00001 53 RPFA int.(cm) 4.1±1.1 2.2±0.5 0.00001 74 Indexes of RPFA were abnormal (>95% confidence limits of normal subjects) in 74% of our patients, while transmitral FV indexes were abnormal in 36%. In addition, RPFAint. correlated with functional class (p

Original languageEnglish
Pages (from-to)424
Number of pages1
JournalJournal of the American Society of Echocardiography
Volume10
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Autore, C., Mallus, M. T., Vizza, C. D., Piccininno, M., Castaldo, M., Cartoni, D., Fedele, F., & Dagianti, A. (1997). Role of pulmonary venous flow velocity indexes in the clinical assessment of patients with hypertrophic cardiomyopathy. Journal of the American Society of Echocardiography, 10(4), 424.