Role of radiotherapy boost in women with ductal carcinoma in situ: A single-center experience in a series of 389 patients

I. Meattini, L. Livi, D. Franceschini, C. Saieva, F. Meacci, L. Marrazzo, B. Bendinelli, V. Scotti, C. De Luca Cardillo, J. Nori, L. Sanchez, L. Orzalesi, P. Bonomo, D. Greto, M. Bucciolini, S. Bianchi, G. Biti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The use of adjuvant radiotherapy in ductal carcinoma in situ is accepted by most radiation oncologists worldwide; the role of a boost on the tumor bed is however more controversial. Materials and methods: We reviewed our Institute experience in DCIS treatment, focusing on main prognostic factors and impact of radiation boost on local relapse. A total of 389 patients treated between 1990 and 2007 were retrospectively analyzed. All patients received adjuvant radiotherapy after breast-conserving surgery for a median dose of 50 Gy; 190 patients (48.8%) received and additional radiation boost on the tumor bed. Results: At a mean follow up of 7.7 years, we recorded 26 local recurrence (6.7%). Concerning local relapse-free survival, at Cox regression univariate analyses

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume39
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Boost radiotherapy
  • Breast cancer
  • Ductal carcinoma in situ
  • Surgical margins
  • Van Nuys prognostic index
  • Young age

ASJC Scopus subject areas

  • Oncology
  • Surgery

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