Role of radiotherapy fractionation in head and neck cancers (MARCH)

an updated meta-analysis

Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, Vincent Grégoire, Matthew Nankivell, Björn Zackrisson, Zbigniew Szutkowski, Rafał Suwiński, Michael G. Poulsen, Brian O'Sullivan, Renzo Corvò, Sarbani Ghosh Laskar, Carlo Fallai, Hideya Yamazaki, Werner Dobrowsky, Kwan Ho Cho, Adam S. Garden, Johannes A. Langendijk, Celia Maria Pais Viegas & 31 others John H. Hay, Mohamed Lotayef, Mahesh K.B. Parmar, Anne Aupérin, Carla van Herpen, Philippe Maingon, Andy M. Trotti, Cai Grau, Jean Pierre Pignon, Pierre Blanchard, Pierre Blanchard, Jean Bourhis, Benjamin Lacas, Jean Pierre Pignon, Jacques Bernier, Quynh Thu Le, Jens Overgaard, Masheh KB Parmar, Andy Trotti, Jai Prakash Agarwal, Anne Aupérin, Kian K. Ang, Hassan K. Awwad, Almalina Bacigalupo, Harry Bartelink, Ellen Benhamou, Renzo Corvò, Carlo Fallai, Giuseppe Sanguineti, Valter Torri, MARCH Collaborative Group

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials. Methods For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009, and July 15, 2015, comparing primary or postoperative conventional fractionation radiotherapy versus altered fractionation radiotherapy (comparison 1) or conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone (comparison 2). Eligible trials had to start randomisation on or after Jan 1, 1970, and completed accrual before Dec 31, 2010; had to have been randomised in a way that precluded prior knowledge of treatment assignment; and had to include patients with non-metastatic squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx undergoing first-line curative treatment. Trials including a non-conventional radiotherapy control group, investigating hypofractionated radiotherapy, or including mostly nasopharyngeal carcinomas were excluded. Trials were grouped in three types of altered fractionation: hyperfractionated, moderately accelerated, and very accelerated. Individual patient data were collected and combined with a fixed-effects model based on the intention-to-treat principle. The primary endpoint was overall survival. Findings Comparison 1 (conventional fractionation radiotherapy vs altered fractionation radiotherapy) included 33 trials and 11 423 patients. Altered fractionation radiotherapy was associated with a significant benefit on overall survival (hazard ratio [HR] 0·94, 95% CI 0·90–0·98; p=0·0033), with an absolute difference at 5 years of 3·1% (95% CI 1·3–4·9) and at 10 years of 1·2% (−0·8 to 3·2). We found a significant interaction (p=0·051) between type of fractionation and treatment effect, the overall survival benefit being restricted to the hyperfractionated group (HR 0·83, 0·74–0·92), with absolute differences at 5 years of 8·1% (3·4 to 12·8) and at 10 years of 3·9% (−0·6 to 8·4). Comparison 2 (conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone) included five trials and 986 patients. Overall survival was significantly worse with altered fractionation radiotherapy compared with concomitant chemoradiotherapy (HR 1·22, 1·05–1·42; p=0·0098), with absolute differences at 5 years of −5·8% (−11·9 to 0·3) and at 10 years of −5·1% (−13·0 to 2·8). Interpretation This update confirms, with more patients and a longer follow-up than the first version of MARCH, that hyperfractionated radiotherapy is, along with concomitant chemoradiotherapy, a standard of care for the treatment of locally advanced head and neck squamous cell cancers. The comparison between hyperfractionated radiotherapy and concomitant chemoradiotherapy remains to be specifically tested. Funding Institut National du Cancer; and Ligue Nationale Contre le Cancer.

Original languageEnglish
Pages (from-to)1221-1237
Number of pages17
JournalThe Lancet Oncology
Volume18
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

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Head and Neck Neoplasms
Meta-Analysis
Radiotherapy
Chemoradiotherapy
Survival
Drug Therapy
Squamous Cell Neoplasms
Hypopharynx
Oropharynx
Bibliography
Therapeutics
Standard of Care

ASJC Scopus subject areas

  • Oncology

Cite this

Lacas, B., Bourhis, J., Overgaard, J., Zhang, Q., Grégoire, V., Nankivell, M., ... MARCH Collaborative Group (2017). Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. The Lancet Oncology, 18(9), 1221-1237. https://doi.org/10.1016/S1470-2045(17)30458-8

Role of radiotherapy fractionation in head and neck cancers (MARCH) : an updated meta-analysis. / Lacas, Benjamin; Bourhis, Jean; Overgaard, Jens; Zhang, Qiang; Grégoire, Vincent; Nankivell, Matthew; Zackrisson, Björn; Szutkowski, Zbigniew; Suwiński, Rafał; Poulsen, Michael G.; O'Sullivan, Brian; Corvò, Renzo; Laskar, Sarbani Ghosh; Fallai, Carlo; Yamazaki, Hideya; Dobrowsky, Werner; Cho, Kwan Ho; Garden, Adam S.; Langendijk, Johannes A.; Viegas, Celia Maria Pais; Hay, John H.; Lotayef, Mohamed; Parmar, Mahesh K.B.; Aupérin, Anne; van Herpen, Carla; Maingon, Philippe; Trotti, Andy M.; Grau, Cai; Pignon, Jean Pierre; Blanchard, Pierre; Blanchard, Pierre; Bourhis, Jean; Lacas, Benjamin; Pignon, Jean Pierre; Bernier, Jacques; Le, Quynh Thu; Overgaard, Jens; Parmar, Masheh KB; Trotti, Andy; Agarwal, Jai Prakash; Aupérin, Anne; Ang, Kian K.; Awwad, Hassan K.; Bacigalupo, Almalina; Bartelink, Harry; Benhamou, Ellen; Corvò, Renzo; Fallai, Carlo; Sanguineti, Giuseppe; Torri, Valter; MARCH Collaborative Group.

In: The Lancet Oncology, Vol. 18, No. 9, 01.09.2017, p. 1221-1237.

Research output: Contribution to journalArticle

Lacas, B, Bourhis, J, Overgaard, J, Zhang, Q, Grégoire, V, Nankivell, M, Zackrisson, B, Szutkowski, Z, Suwiński, R, Poulsen, MG, O'Sullivan, B, Corvò, R, Laskar, SG, Fallai, C, Yamazaki, H, Dobrowsky, W, Cho, KH, Garden, AS, Langendijk, JA, Viegas, CMP, Hay, JH, Lotayef, M, Parmar, MKB, Aupérin, A, van Herpen, C, Maingon, P, Trotti, AM, Grau, C, Pignon, JP, Blanchard, P, Blanchard, P, Bourhis, J, Lacas, B, Pignon, JP, Bernier, J, Le, QT, Overgaard, J, Parmar, MKB, Trotti, A, Agarwal, JP, Aupérin, A, Ang, KK, Awwad, HK, Bacigalupo, A, Bartelink, H, Benhamou, E, Corvò, R, Fallai, C, Sanguineti, G, Torri, V & MARCH Collaborative Group 2017, 'Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis', The Lancet Oncology, vol. 18, no. 9, pp. 1221-1237. https://doi.org/10.1016/S1470-2045(17)30458-8
Lacas B, Bourhis J, Overgaard J, Zhang Q, Grégoire V, Nankivell M et al. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. The Lancet Oncology. 2017 Sep 1;18(9):1221-1237. https://doi.org/10.1016/S1470-2045(17)30458-8
Lacas, Benjamin ; Bourhis, Jean ; Overgaard, Jens ; Zhang, Qiang ; Grégoire, Vincent ; Nankivell, Matthew ; Zackrisson, Björn ; Szutkowski, Zbigniew ; Suwiński, Rafał ; Poulsen, Michael G. ; O'Sullivan, Brian ; Corvò, Renzo ; Laskar, Sarbani Ghosh ; Fallai, Carlo ; Yamazaki, Hideya ; Dobrowsky, Werner ; Cho, Kwan Ho ; Garden, Adam S. ; Langendijk, Johannes A. ; Viegas, Celia Maria Pais ; Hay, John H. ; Lotayef, Mohamed ; Parmar, Mahesh K.B. ; Aupérin, Anne ; van Herpen, Carla ; Maingon, Philippe ; Trotti, Andy M. ; Grau, Cai ; Pignon, Jean Pierre ; Blanchard, Pierre ; Blanchard, Pierre ; Bourhis, Jean ; Lacas, Benjamin ; Pignon, Jean Pierre ; Bernier, Jacques ; Le, Quynh Thu ; Overgaard, Jens ; Parmar, Masheh KB ; Trotti, Andy ; Agarwal, Jai Prakash ; Aupérin, Anne ; Ang, Kian K. ; Awwad, Hassan K. ; Bacigalupo, Almalina ; Bartelink, Harry ; Benhamou, Ellen ; Corvò, Renzo ; Fallai, Carlo ; Sanguineti, Giuseppe ; Torri, Valter ; MARCH Collaborative Group. / Role of radiotherapy fractionation in head and neck cancers (MARCH) : an updated meta-analysis. In: The Lancet Oncology. 2017 ; Vol. 18, No. 9. pp. 1221-1237.
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abstract = "Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials. Methods For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009, and July 15, 2015, comparing primary or postoperative conventional fractionation radiotherapy versus altered fractionation radiotherapy (comparison 1) or conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone (comparison 2). Eligible trials had to start randomisation on or after Jan 1, 1970, and completed accrual before Dec 31, 2010; had to have been randomised in a way that precluded prior knowledge of treatment assignment; and had to include patients with non-metastatic squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx undergoing first-line curative treatment. Trials including a non-conventional radiotherapy control group, investigating hypofractionated radiotherapy, or including mostly nasopharyngeal carcinomas were excluded. Trials were grouped in three types of altered fractionation: hyperfractionated, moderately accelerated, and very accelerated. Individual patient data were collected and combined with a fixed-effects model based on the intention-to-treat principle. The primary endpoint was overall survival. Findings Comparison 1 (conventional fractionation radiotherapy vs altered fractionation radiotherapy) included 33 trials and 11 423 patients. Altered fractionation radiotherapy was associated with a significant benefit on overall survival (hazard ratio [HR] 0·94, 95{\%} CI 0·90–0·98; p=0·0033), with an absolute difference at 5 years of 3·1{\%} (95{\%} CI 1·3–4·9) and at 10 years of 1·2{\%} (−0·8 to 3·2). We found a significant interaction (p=0·051) between type of fractionation and treatment effect, the overall survival benefit being restricted to the hyperfractionated group (HR 0·83, 0·74–0·92), with absolute differences at 5 years of 8·1{\%} (3·4 to 12·8) and at 10 years of 3·9{\%} (−0·6 to 8·4). Comparison 2 (conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone) included five trials and 986 patients. Overall survival was significantly worse with altered fractionation radiotherapy compared with concomitant chemoradiotherapy (HR 1·22, 1·05–1·42; p=0·0098), with absolute differences at 5 years of −5·8{\%} (−11·9 to 0·3) and at 10 years of −5·1{\%} (−13·0 to 2·8). Interpretation This update confirms, with more patients and a longer follow-up than the first version of MARCH, that hyperfractionated radiotherapy is, along with concomitant chemoradiotherapy, a standard of care for the treatment of locally advanced head and neck squamous cell cancers. The comparison between hyperfractionated radiotherapy and concomitant chemoradiotherapy remains to be specifically tested. Funding Institut National du Cancer; and Ligue Nationale Contre le Cancer.",
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language = "English",
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TY - JOUR

T1 - Role of radiotherapy fractionation in head and neck cancers (MARCH)

T2 - an updated meta-analysis

AU - Lacas, Benjamin

AU - Bourhis, Jean

AU - Overgaard, Jens

AU - Zhang, Qiang

AU - Grégoire, Vincent

AU - Nankivell, Matthew

AU - Zackrisson, Björn

AU - Szutkowski, Zbigniew

AU - Suwiński, Rafał

AU - Poulsen, Michael G.

AU - O'Sullivan, Brian

AU - Corvò, Renzo

AU - Laskar, Sarbani Ghosh

AU - Fallai, Carlo

AU - Yamazaki, Hideya

AU - Dobrowsky, Werner

AU - Cho, Kwan Ho

AU - Garden, Adam S.

AU - Langendijk, Johannes A.

AU - Viegas, Celia Maria Pais

AU - Hay, John H.

AU - Lotayef, Mohamed

AU - Parmar, Mahesh K.B.

AU - Aupérin, Anne

AU - van Herpen, Carla

AU - Maingon, Philippe

AU - Trotti, Andy M.

AU - Grau, Cai

AU - Pignon, Jean Pierre

AU - Blanchard, Pierre

AU - Blanchard, Pierre

AU - Bourhis, Jean

AU - Lacas, Benjamin

AU - Pignon, Jean Pierre

AU - Bernier, Jacques

AU - Le, Quynh Thu

AU - Overgaard, Jens

AU - Parmar, Masheh KB

AU - Trotti, Andy

AU - Agarwal, Jai Prakash

AU - Aupérin, Anne

AU - Ang, Kian K.

AU - Awwad, Hassan K.

AU - Bacigalupo, Almalina

AU - Bartelink, Harry

AU - Benhamou, Ellen

AU - Corvò, Renzo

AU - Fallai, Carlo

AU - Sanguineti, Giuseppe

AU - Torri, Valter

AU - MARCH Collaborative Group

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials. Methods For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009, and July 15, 2015, comparing primary or postoperative conventional fractionation radiotherapy versus altered fractionation radiotherapy (comparison 1) or conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone (comparison 2). Eligible trials had to start randomisation on or after Jan 1, 1970, and completed accrual before Dec 31, 2010; had to have been randomised in a way that precluded prior knowledge of treatment assignment; and had to include patients with non-metastatic squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx undergoing first-line curative treatment. Trials including a non-conventional radiotherapy control group, investigating hypofractionated radiotherapy, or including mostly nasopharyngeal carcinomas were excluded. Trials were grouped in three types of altered fractionation: hyperfractionated, moderately accelerated, and very accelerated. Individual patient data were collected and combined with a fixed-effects model based on the intention-to-treat principle. The primary endpoint was overall survival. Findings Comparison 1 (conventional fractionation radiotherapy vs altered fractionation radiotherapy) included 33 trials and 11 423 patients. Altered fractionation radiotherapy was associated with a significant benefit on overall survival (hazard ratio [HR] 0·94, 95% CI 0·90–0·98; p=0·0033), with an absolute difference at 5 years of 3·1% (95% CI 1·3–4·9) and at 10 years of 1·2% (−0·8 to 3·2). We found a significant interaction (p=0·051) between type of fractionation and treatment effect, the overall survival benefit being restricted to the hyperfractionated group (HR 0·83, 0·74–0·92), with absolute differences at 5 years of 8·1% (3·4 to 12·8) and at 10 years of 3·9% (−0·6 to 8·4). Comparison 2 (conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone) included five trials and 986 patients. Overall survival was significantly worse with altered fractionation radiotherapy compared with concomitant chemoradiotherapy (HR 1·22, 1·05–1·42; p=0·0098), with absolute differences at 5 years of −5·8% (−11·9 to 0·3) and at 10 years of −5·1% (−13·0 to 2·8). Interpretation This update confirms, with more patients and a longer follow-up than the first version of MARCH, that hyperfractionated radiotherapy is, along with concomitant chemoradiotherapy, a standard of care for the treatment of locally advanced head and neck squamous cell cancers. The comparison between hyperfractionated radiotherapy and concomitant chemoradiotherapy remains to be specifically tested. Funding Institut National du Cancer; and Ligue Nationale Contre le Cancer.

AB - Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials. Methods For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009, and July 15, 2015, comparing primary or postoperative conventional fractionation radiotherapy versus altered fractionation radiotherapy (comparison 1) or conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone (comparison 2). Eligible trials had to start randomisation on or after Jan 1, 1970, and completed accrual before Dec 31, 2010; had to have been randomised in a way that precluded prior knowledge of treatment assignment; and had to include patients with non-metastatic squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx undergoing first-line curative treatment. Trials including a non-conventional radiotherapy control group, investigating hypofractionated radiotherapy, or including mostly nasopharyngeal carcinomas were excluded. Trials were grouped in three types of altered fractionation: hyperfractionated, moderately accelerated, and very accelerated. Individual patient data were collected and combined with a fixed-effects model based on the intention-to-treat principle. The primary endpoint was overall survival. Findings Comparison 1 (conventional fractionation radiotherapy vs altered fractionation radiotherapy) included 33 trials and 11 423 patients. Altered fractionation radiotherapy was associated with a significant benefit on overall survival (hazard ratio [HR] 0·94, 95% CI 0·90–0·98; p=0·0033), with an absolute difference at 5 years of 3·1% (95% CI 1·3–4·9) and at 10 years of 1·2% (−0·8 to 3·2). We found a significant interaction (p=0·051) between type of fractionation and treatment effect, the overall survival benefit being restricted to the hyperfractionated group (HR 0·83, 0·74–0·92), with absolute differences at 5 years of 8·1% (3·4 to 12·8) and at 10 years of 3·9% (−0·6 to 8·4). Comparison 2 (conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone) included five trials and 986 patients. Overall survival was significantly worse with altered fractionation radiotherapy compared with concomitant chemoradiotherapy (HR 1·22, 1·05–1·42; p=0·0098), with absolute differences at 5 years of −5·8% (−11·9 to 0·3) and at 10 years of −5·1% (−13·0 to 2·8). Interpretation This update confirms, with more patients and a longer follow-up than the first version of MARCH, that hyperfractionated radiotherapy is, along with concomitant chemoradiotherapy, a standard of care for the treatment of locally advanced head and neck squamous cell cancers. The comparison between hyperfractionated radiotherapy and concomitant chemoradiotherapy remains to be specifically tested. Funding Institut National du Cancer; and Ligue Nationale Contre le Cancer.

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