Role of radiotherapy in patients with early-stage diffuse large B-cell lymphoma of Waldeyer's ring in remission after anthracycline-containing chemotherapy

Michael Mian, Andrés J M Ferreri, Andrea Rossi, Annarita Conconi, Richard Tsang, Mary K. Gospodarowicz, Elena Oldani, Massimo Federico, Stefano Luminari, Enrico M. Pogliani, Fausto Rossini, Maria E. Cabrera, Maurizio Martelli, Gonzalo Gutierrez-Garcia, Mario Busetto, Franco Cavalli, Emanuele Zucca, Alessandro Rambaldi, Sergio Cortelazzo

Research output: Contribution to journalArticle

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Abstract

Consolidation radiotherapy (cRT) in patients with stage I/II diffuse large B-cell lymphoma of the Waldeyer's ring (WR-DLBCL) in complete remission (CR) after induction chemotherapy (CHT) is often associated with relevant acute and chronic toxicity, and its impact on survival remains to be defined. A total of 184 patients in CR after anthracycline-based chemotherapy were retrospectively analyzed: 62 underwent CHT alone (CHT group), while 122 (66%) patients were referred to cRT (CHT + RT group). After a median follow-up of 54 months, 36 patients (20%) experienced relapse: 19% in the CHT group and 20% in the CHT + RT group. At the time of analysis 47 (76%) CHT patients and 97 (80%) CHT + RT patients were alive. Five-year overall survival (OS), disease-free survival (DFS) and lymphoma-specific survival (LSS) were 80%, 74% and 86%, respectively. Five-year OS was significantly prolonged in the CHT + RT group, while DFS and LSS were similar between groups. This discrepancy was attributed to a high percentage of deaths due to unrelated causes in CHT patients. cRT does not prolong LSS in patients with early-stage WR-DLBCL in CR after anthracycline-containing chemotherapy. An international confirmatory trial is warranted.

Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalLeukemia and Lymphoma
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Anthracyclines
Radiotherapy
Drug Therapy
Survival
Lymphoma
Disease-Free Survival
Remission Induction
Induction Chemotherapy
Recurrence

Keywords

  • Chemotherapy
  • DLBCL
  • Lymphoma
  • Radiotherapy
  • Waldeyer

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Role of radiotherapy in patients with early-stage diffuse large B-cell lymphoma of Waldeyer's ring in remission after anthracycline-containing chemotherapy. / Mian, Michael; Ferreri, Andrés J M; Rossi, Andrea; Conconi, Annarita; Tsang, Richard; Gospodarowicz, Mary K.; Oldani, Elena; Federico, Massimo; Luminari, Stefano; Pogliani, Enrico M.; Rossini, Fausto; Cabrera, Maria E.; Martelli, Maurizio; Gutierrez-Garcia, Gonzalo; Busetto, Mario; Cavalli, Franco; Zucca, Emanuele; Rambaldi, Alessandro; Cortelazzo, Sergio.

In: Leukemia and Lymphoma, Vol. 54, No. 1, 01.2013, p. 62-68.

Research output: Contribution to journalArticle

Mian, M, Ferreri, AJM, Rossi, A, Conconi, A, Tsang, R, Gospodarowicz, MK, Oldani, E, Federico, M, Luminari, S, Pogliani, EM, Rossini, F, Cabrera, ME, Martelli, M, Gutierrez-Garcia, G, Busetto, M, Cavalli, F, Zucca, E, Rambaldi, A & Cortelazzo, S 2013, 'Role of radiotherapy in patients with early-stage diffuse large B-cell lymphoma of Waldeyer's ring in remission after anthracycline-containing chemotherapy', Leukemia and Lymphoma, vol. 54, no. 1, pp. 62-68. https://doi.org/10.3109/10428194.2012.710907
Mian, Michael ; Ferreri, Andrés J M ; Rossi, Andrea ; Conconi, Annarita ; Tsang, Richard ; Gospodarowicz, Mary K. ; Oldani, Elena ; Federico, Massimo ; Luminari, Stefano ; Pogliani, Enrico M. ; Rossini, Fausto ; Cabrera, Maria E. ; Martelli, Maurizio ; Gutierrez-Garcia, Gonzalo ; Busetto, Mario ; Cavalli, Franco ; Zucca, Emanuele ; Rambaldi, Alessandro ; Cortelazzo, Sergio. / Role of radiotherapy in patients with early-stage diffuse large B-cell lymphoma of Waldeyer's ring in remission after anthracycline-containing chemotherapy. In: Leukemia and Lymphoma. 2013 ; Vol. 54, No. 1. pp. 62-68.
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abstract = "Consolidation radiotherapy (cRT) in patients with stage I/II diffuse large B-cell lymphoma of the Waldeyer's ring (WR-DLBCL) in complete remission (CR) after induction chemotherapy (CHT) is often associated with relevant acute and chronic toxicity, and its impact on survival remains to be defined. A total of 184 patients in CR after anthracycline-based chemotherapy were retrospectively analyzed: 62 underwent CHT alone (CHT group), while 122 (66{\%}) patients were referred to cRT (CHT + RT group). After a median follow-up of 54 months, 36 patients (20{\%}) experienced relapse: 19{\%} in the CHT group and 20{\%} in the CHT + RT group. At the time of analysis 47 (76{\%}) CHT patients and 97 (80{\%}) CHT + RT patients were alive. Five-year overall survival (OS), disease-free survival (DFS) and lymphoma-specific survival (LSS) were 80{\%}, 74{\%} and 86{\%}, respectively. Five-year OS was significantly prolonged in the CHT + RT group, while DFS and LSS were similar between groups. This discrepancy was attributed to a high percentage of deaths due to unrelated causes in CHT patients. cRT does not prolong LSS in patients with early-stage WR-DLBCL in CR after anthracycline-containing chemotherapy. An international confirmatory trial is warranted.",
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AU - Ferreri, Andrés J M

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AU - Conconi, Annarita

AU - Tsang, Richard

AU - Gospodarowicz, Mary K.

AU - Oldani, Elena

AU - Federico, Massimo

AU - Luminari, Stefano

AU - Pogliani, Enrico M.

AU - Rossini, Fausto

AU - Cabrera, Maria E.

AU - Martelli, Maurizio

AU - Gutierrez-Garcia, Gonzalo

AU - Busetto, Mario

AU - Cavalli, Franco

AU - Zucca, Emanuele

AU - Rambaldi, Alessandro

AU - Cortelazzo, Sergio

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N2 - Consolidation radiotherapy (cRT) in patients with stage I/II diffuse large B-cell lymphoma of the Waldeyer's ring (WR-DLBCL) in complete remission (CR) after induction chemotherapy (CHT) is often associated with relevant acute and chronic toxicity, and its impact on survival remains to be defined. A total of 184 patients in CR after anthracycline-based chemotherapy were retrospectively analyzed: 62 underwent CHT alone (CHT group), while 122 (66%) patients were referred to cRT (CHT + RT group). After a median follow-up of 54 months, 36 patients (20%) experienced relapse: 19% in the CHT group and 20% in the CHT + RT group. At the time of analysis 47 (76%) CHT patients and 97 (80%) CHT + RT patients were alive. Five-year overall survival (OS), disease-free survival (DFS) and lymphoma-specific survival (LSS) were 80%, 74% and 86%, respectively. Five-year OS was significantly prolonged in the CHT + RT group, while DFS and LSS were similar between groups. This discrepancy was attributed to a high percentage of deaths due to unrelated causes in CHT patients. cRT does not prolong LSS in patients with early-stage WR-DLBCL in CR after anthracycline-containing chemotherapy. An international confirmatory trial is warranted.

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