Role of radiotherapy in the treatment of epidemic Kaposi's sarcoma: Experience with sixty-five cases

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Abstract

Background: Treatment of Kaposi's sarcoma (KS) associated with HIV infection should improve often disfiguring lesions, with an acceptable cosmetic outcome; relieve associated signs and symptoms (pain and edema); and have no adverse effects on the patient's already impaired immune status. Objective: Our purpose was to determine the role of x-ray therapy in the treatment of KS. Methods: Contact x-ray therapy and half-deep x-ray therapy were used to treat 594 lesions in 65 patients with KS, who were observed for 1 to 43 months (mean, 9 months). Results: Complete remission was achieved with pigmentation in 405 lesions (68.3%), with good cosmetic results in 105 (17.7%), and with hypopigmentation in three (0.5%). In 80 lesions (13.5%) only size reduction or pain palliation were achieved. Fourteen lesions (2.4%) relapsed 2 to 9 months after treatment. Conclusion: X-ray therapy is well tolerated and meets the specified requirements for the treatment of KS.

Original languageEnglish
Pages (from-to)1000-1003
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume32
Issue number6
DOIs
Publication statusPublished - 1995

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Kaposi's Sarcoma
Radiotherapy
X-Rays
Cosmetics
Therapeutics
X-Ray Therapy
Hypopigmentation
Pain
Pigmentation
Signs and Symptoms
HIV Infections
Edema

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Role of radiotherapy in the treatment of epidemic Kaposi's sarcoma: Experience with sixty-five cases",
abstract = "Background: Treatment of Kaposi's sarcoma (KS) associated with HIV infection should improve often disfiguring lesions, with an acceptable cosmetic outcome; relieve associated signs and symptoms (pain and edema); and have no adverse effects on the patient's already impaired immune status. Objective: Our purpose was to determine the role of x-ray therapy in the treatment of KS. Methods: Contact x-ray therapy and half-deep x-ray therapy were used to treat 594 lesions in 65 patients with KS, who were observed for 1 to 43 months (mean, 9 months). Results: Complete remission was achieved with pigmentation in 405 lesions (68.3{\%}), with good cosmetic results in 105 (17.7{\%}), and with hypopigmentation in three (0.5{\%}). In 80 lesions (13.5{\%}) only size reduction or pain palliation were achieved. Fourteen lesions (2.4{\%}) relapsed 2 to 9 months after treatment. Conclusion: X-ray therapy is well tolerated and meets the specified requirements for the treatment of KS.",
author = "Roberta Piccinno and Massimo Caccialanza and Marco Cusini",
year = "1995",
doi = "10.1016/0190-9622(95)91339-4",
language = "English",
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pages = "1000--1003",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "6",

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TY - JOUR

T1 - Role of radiotherapy in the treatment of epidemic Kaposi's sarcoma

T2 - Experience with sixty-five cases

AU - Piccinno, Roberta

AU - Caccialanza, Massimo

AU - Cusini, Marco

PY - 1995

Y1 - 1995

N2 - Background: Treatment of Kaposi's sarcoma (KS) associated with HIV infection should improve often disfiguring lesions, with an acceptable cosmetic outcome; relieve associated signs and symptoms (pain and edema); and have no adverse effects on the patient's already impaired immune status. Objective: Our purpose was to determine the role of x-ray therapy in the treatment of KS. Methods: Contact x-ray therapy and half-deep x-ray therapy were used to treat 594 lesions in 65 patients with KS, who were observed for 1 to 43 months (mean, 9 months). Results: Complete remission was achieved with pigmentation in 405 lesions (68.3%), with good cosmetic results in 105 (17.7%), and with hypopigmentation in three (0.5%). In 80 lesions (13.5%) only size reduction or pain palliation were achieved. Fourteen lesions (2.4%) relapsed 2 to 9 months after treatment. Conclusion: X-ray therapy is well tolerated and meets the specified requirements for the treatment of KS.

AB - Background: Treatment of Kaposi's sarcoma (KS) associated with HIV infection should improve often disfiguring lesions, with an acceptable cosmetic outcome; relieve associated signs and symptoms (pain and edema); and have no adverse effects on the patient's already impaired immune status. Objective: Our purpose was to determine the role of x-ray therapy in the treatment of KS. Methods: Contact x-ray therapy and half-deep x-ray therapy were used to treat 594 lesions in 65 patients with KS, who were observed for 1 to 43 months (mean, 9 months). Results: Complete remission was achieved with pigmentation in 405 lesions (68.3%), with good cosmetic results in 105 (17.7%), and with hypopigmentation in three (0.5%). In 80 lesions (13.5%) only size reduction or pain palliation were achieved. Fourteen lesions (2.4%) relapsed 2 to 9 months after treatment. Conclusion: X-ray therapy is well tolerated and meets the specified requirements for the treatment of KS.

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