Role of receptor heterodimers in the development of l-dopa-induced dyskinesias in the 6-hydroxydopamine rat model of Parkinson's disease

Chiara Fiorentini, Chiara Busi, PierFranco Spano, Cristina Missale

Research output: Contribution to journalArticle

Abstract

Chronic l-dopa administration is associated with development of dyskinesias. The molecular mechanisms of these side-effects, however, remain elusive. Dopamine (DA) receptors interact with other receptors to form highly organized complexes where their activity is finely tuned by several proteins. The DA D1R forms a heteromeric complex with the NMDA receptor (NMDAR) and this interaction influences the trafficking of both receptors. Using the 6-hydroxydopamine rat model of Parkinson's disease, we report a correlation between the development of l-dopa-induced dyskinesias and changes in synaptic D1R/NMDAR complexes.

Original languageEnglish
JournalParkinsonism and Related Disorders
Volume14
Issue numberSUPPL.2
DOIs
Publication statusPublished - Jul 2008

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Keywords

  • D1 receptor
  • Desensitization
  • Dimerization
  • Dopamine
  • Glutamate
  • NMDA receptor

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology

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