Ruolo dell'insufficienza renale nella patogenesi delle reazioni avverse a farmaci negli anziani

Andrea Corsonello; Claudio Pedone; Francesco Corica; Bruno Mazzei; Chiara Mussi; Angelo Di Iorio; Raffaele Antonelli Incalzi

Ruolo dell'insufficienza renale nella patogenesi delle reazioni avverse a farmaci negli anziani

Translated title of the contribution: Role of renal failure in the pathogenesis of adverse drug reactions in the elderly

Andrea Corsonello, Claudio Pedone, Francesco Corica, Bruno Mazzei, Chiara Mussi, Angelo Di Iorio, Raffaele Antonelli Incalzi

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

The high prevalence of multiple chronic disorders and polypharmacotherapy expose elderly patient to an increased risk of adverse drug reactions. Aging is associated with relevant morphological and functional changes in the kidney, with consequent changes in the pharmacokinetics of hydrosoluble drugs. Changes in renal function are not always clinically evident, and a concealed renal failure can lead to an increased risk of adverse drug reactions to hydrosoluble drugs. Targeting these at-risk patients could contribute to reduce the risk of adverse drug reactions with relevant cost saving.

Translated title of the contribution	Role of renal failure in the pathogenesis of adverse drug reactions in the elderly
Original language	Italian
Pages (from-to)	90-93
Number of pages	4
Journal	Recenti Progressi in Medicina
Volume	97
Issue number	2
Publication status	Published - Feb 2006

ASJC Scopus subject areas

Medicine(all)

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Cite this

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title = "Ruolo dell'insufficienza renale nella patogenesi delle reazioni avverse a farmaci negli anziani",

abstract = "The high prevalence of multiple chronic disorders and polypharmacotherapy expose elderly patient to an increased risk of adverse drug reactions. Aging is associated with relevant morphological and functional changes in the kidney, with consequent changes in the pharmacokinetics of hydrosoluble drugs. Changes in renal function are not always clinically evident, and a concealed renal failure can lead to an increased risk of adverse drug reactions to hydrosoluble drugs. Targeting these at-risk patients could contribute to reduce the risk of adverse drug reactions with relevant cost saving.",

keywords = "Adverse drug reactions, Elderly, Glomerular filtration rate, Renal failure",

author = "Andrea Corsonello and Claudio Pedone and Francesco Corica and Bruno Mazzei and Chiara Mussi and {Di Iorio}, Angelo and Incalzi, {Raffaele Antonelli}",

year = "2006",

month = feb,

language = "Italian",

volume = "97",

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journal = "Recenti Progressi in Medicina",

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T1 - Ruolo dell'insufficienza renale nella patogenesi delle reazioni avverse a farmaci negli anziani

AU - Corsonello, Andrea

AU - Pedone, Claudio

AU - Corica, Francesco

AU - Mazzei, Bruno

AU - Mussi, Chiara

AU - Di Iorio, Angelo

AU - Incalzi, Raffaele Antonelli

PY - 2006/2

Y1 - 2006/2

N2 - The high prevalence of multiple chronic disorders and polypharmacotherapy expose elderly patient to an increased risk of adverse drug reactions. Aging is associated with relevant morphological and functional changes in the kidney, with consequent changes in the pharmacokinetics of hydrosoluble drugs. Changes in renal function are not always clinically evident, and a concealed renal failure can lead to an increased risk of adverse drug reactions to hydrosoluble drugs. Targeting these at-risk patients could contribute to reduce the risk of adverse drug reactions with relevant cost saving.

AB - The high prevalence of multiple chronic disorders and polypharmacotherapy expose elderly patient to an increased risk of adverse drug reactions. Aging is associated with relevant morphological and functional changes in the kidney, with consequent changes in the pharmacokinetics of hydrosoluble drugs. Changes in renal function are not always clinically evident, and a concealed renal failure can lead to an increased risk of adverse drug reactions to hydrosoluble drugs. Targeting these at-risk patients could contribute to reduce the risk of adverse drug reactions with relevant cost saving.

KW - Adverse drug reactions

KW - Elderly

KW - Glomerular filtration rate

KW - Renal failure

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JO - Recenti Progressi in Medicina

JF - Recenti Progressi in Medicina

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