Ruolo dell'insufficienza renale nella patogenesi delle reazioni avverse a farmaci negli anziani

Translated title of the contribution: Role of renal failure in the pathogenesis of adverse drug reactions in the elderly

Andrea Corsonello, Claudio Pedone, Francesco Corica, Bruno Mazzei, Chiara Mussi, Angelo Di Iorio, Raffaele Antonelli Incalzi

Research output: Contribution to journalArticlepeer-review

Abstract

The high prevalence of multiple chronic disorders and polypharmacotherapy expose elderly patient to an increased risk of adverse drug reactions. Aging is associated with relevant morphological and functional changes in the kidney, with consequent changes in the pharmacokinetics of hydrosoluble drugs. Changes in renal function are not always clinically evident, and a concealed renal failure can lead to an increased risk of adverse drug reactions to hydrosoluble drugs. Targeting these at-risk patients could contribute to reduce the risk of adverse drug reactions with relevant cost saving.

Translated title of the contributionRole of renal failure in the pathogenesis of adverse drug reactions in the elderly
Original languageItalian
Pages (from-to)90-93
Number of pages4
JournalRecenti Progressi in Medicina
Volume97
Issue number2
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Medicine(all)

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