RUOLO DEL PROFILO RENINICO E DELL'ETA' NELLA SCELTA DELL'APPROCCIO TERAPEUTICO DELL'IPERTENSIONE ARTERIOSA

Translated title of the contribution: Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension

N. Glorioso, P. Madeddu, P. Dessi Fulgheri, G. Sanna, C. Fiori, S. Dettori, F. Cocco, A. Rappelli

Research output: Contribution to journalArticlepeer-review

Abstract

A group of 116 patients with grade I-II (W.H.O.) essential hypertension was studied. A diuretic treatment was instituted as a first step of therapy in 50 patients while the remaining 66 were first treated with beta-blockers. After 6 weeks of treatment the drugs were combined in those patients who did not achieve blood pressure control; this combination therapy was again maintained for 6 weeks and, if necessary, a vasodilating agent was added thereafter. The results show that with diuretic treatment alone diastolic blood pressure was brought to normal values (<95 mmHg) in 3/4 of our low renin patients, in 2/3 of normal renin and in 1/3 of high renin hypertensives. On the contrary among the group of patients treated with a beta-blocker alone more than half of the high and normal renin patients were controlled, whereas this goal was achieved in only 1/4 of the low renin patients. Similar behaviour was observed subdividing the subjects in young (<35 yr), middle-aged (36-49 yr) and older (> 50 yr) patients. In conclusion our data indicate that age must be taken into account in classifying hypertensive patients in renin subgroups. In addition if a renin-sodium profile is available, it can be useful in choosing between diuretics or beta-blockers as a first step treatment. Alternatively, younger patients are more likely to have better hypotensive responses with beta-blocker whereas in older patients antihypertensive treatment should preferentially be started with diuretics alone.

Translated title of the contributionRole of renin profile and age in the choice of the therapeutic approach of arterial hypertension
Original languageItalian
Pages (from-to)2117-2125
Number of pages9
JournalGiornale Italiano di Cardiologia
Volume11
Issue number12
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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