Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: Focus on recent discoveries

V. Foti Cuzzola, R. Ciurleo, S. Giacoppo, S. Marino, P. Bramanti

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in several areas of the central nervous system (CNS). Substantial evidence has documented a common inflammatory mechanism in neurodegeneration. It is known that classical anti-inflammatory agents, steroids and nonsteroidal anti-inflammatory drugs, have not played a major role in the management of CNS inflammatory conditions. This may be partly due to the natural compartmentation of the brain by the blood-brain barrier. Thus, there is much interest in developing novel anti-inflammatory drugs that may help to prevent or ameliorate CNS inflammation. Resveratrol (RSV) has received considerable attention over the last several decades. Experimental studies have revealed its benefits in several human disease models, including cardio- and neuro-protection, immune regulation and cancer chemoprevention. The broad action spectrum of RSV is explained by the involvement of numerous signaling networks and cellular effector mechanisms. Among them, apoptotic and antioxidant targets have been implicated. Recently, also anti-neuroinflammatory activity has been observed. A number of studies demonstrated that RSV mediates the downregulation of various inflammatory biomarkers such as tumor necrosis factor, cyclooxygenase 2, inducible nitric oxide synthase and interleukins. This activity seems to depend on some structural features of RSV such as the number and the position of hydroxyl groups. In this review, a comprehensive account of multiple intracellular RSV targets involved in neuroinflammation and its analogues design will be treated, pointing to structure/activity relationships.

Original languageEnglish
Pages (from-to)849-862
Number of pages14
JournalCNS and Neurological Disorders - Drug Targets
Volume10
Issue number7
Publication statusPublished - Nov 2011

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Neurodegenerative Diseases
Central Nervous System
Non-Steroidal Anti-Inflammatory Agents
Blood-Brain Barrier
Therapeutics
Interleukins
Chemoprevention
Nitric Oxide Synthase Type II
Cyclooxygenase 2
Structure-Activity Relationship
Pharmaceutical Preparations
Hydroxyl Radical
Anti-Inflammatory Agents
Down-Regulation
Tumor Necrosis Factor-alpha
Antioxidants
Biomarkers
Steroids
resveratrol
Inflammation

Keywords

  • Cyclooxygenase-2
  • Neurodegenerative diseases
  • Neuroinflammation
  • Nuclear factor-kB
  • Resveratrol
  • Resveratrol analogues
  • Sirtuin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

Cite this

Role of resveratrol and its analogues in the treatment of neurodegenerative diseases : Focus on recent discoveries. / Cuzzola, V. Foti; Ciurleo, R.; Giacoppo, S.; Marino, S.; Bramanti, P.

In: CNS and Neurological Disorders - Drug Targets, Vol. 10, No. 7, 11.2011, p. 849-862.

Research output: Contribution to journalArticle

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