TY - JOUR
T1 - Role of salvage stereotactic body radiation therapy in post-surgical loco-regional recurrence in a selected population of non-small cell lung cancer patients
AU - Agolli, Linda
AU - Valeriani, Maurizio
AU - Carnevale, Alessia
AU - Falco, Teresa
AU - Bracci, Stefano
AU - De Sanctis, Vitaliana
AU - Minniti, Giuseppe
AU - Enrici, Riccardo Maurizi
AU - Osti, Mattia Falchetto
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Aim: This is a retrospective analysis of a selected series of high-risk non-small cell lung cancer (NSCLC) patients with post-surgical loco-regional relapse treated with salvage stereotactic body radiotherapy (SBRT). Outcome and toxicity profiles were assessed. Patients and Methods: Twenty-eight patients (unfit for surgery or systemic therapy) with 30 lesions underwent salvage SBRT as an alternative therapy because of advanced age, co-morbid conditions or no response obtained from other treatments. Results: Complete and partial responses were 16% and 70%, respectively. Local progression was observed in 3 patients. Regional relapse occurred in 5 patients. Distant progression occurred in 10 patients. The 2-year overall survival (OS) and disease-free survival (DFS) were 57.5% and 36.6%, respectively. Radiation acute pneumonitis occurred as follows: three patients developed grade 1, two patients experienced grade 2 and one patient experienced grade 3 toxicity. Conclusion: Stereotactic body radiotherapy could have an alternative role in isolated loco-regional relapse in patients unfit or resistant to other therapies.
AB - Aim: This is a retrospective analysis of a selected series of high-risk non-small cell lung cancer (NSCLC) patients with post-surgical loco-regional relapse treated with salvage stereotactic body radiotherapy (SBRT). Outcome and toxicity profiles were assessed. Patients and Methods: Twenty-eight patients (unfit for surgery or systemic therapy) with 30 lesions underwent salvage SBRT as an alternative therapy because of advanced age, co-morbid conditions or no response obtained from other treatments. Results: Complete and partial responses were 16% and 70%, respectively. Local progression was observed in 3 patients. Regional relapse occurred in 5 patients. Distant progression occurred in 10 patients. The 2-year overall survival (OS) and disease-free survival (DFS) were 57.5% and 36.6%, respectively. Radiation acute pneumonitis occurred as follows: three patients developed grade 1, two patients experienced grade 2 and one patient experienced grade 3 toxicity. Conclusion: Stereotactic body radiotherapy could have an alternative role in isolated loco-regional relapse in patients unfit or resistant to other therapies.
KW - Local control
KW - Non-small cell lung cancer
KW - Post-surgical recurrence
KW - Salvage stereotactic radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84924956113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924956113&partnerID=8YFLogxK
M3 - Article
C2 - 25750343
AN - SCOPUS:84924956113
VL - 35
SP - 1783
EP - 1790
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 3
ER -