Role of salvage stereotactic body radiation therapy in post-surgical loco-regional recurrence in a selected population of non-small cell lung cancer patients

Linda Agolli, Maurizio Valeriani, Alessia Carnevale, Teresa Falco, Stefano Bracci, Vitaliana De Sanctis, Giuseppe Minniti, Riccardo Maurizi Enrici, Mattia Falchetto Osti

Research output: Contribution to journalArticle

Abstract

Aim: This is a retrospective analysis of a selected series of high-risk non-small cell lung cancer (NSCLC) patients with post-surgical loco-regional relapse treated with salvage stereotactic body radiotherapy (SBRT). Outcome and toxicity profiles were assessed. Patients and Methods: Twenty-eight patients (unfit for surgery or systemic therapy) with 30 lesions underwent salvage SBRT as an alternative therapy because of advanced age, co-morbid conditions or no response obtained from other treatments. Results: Complete and partial responses were 16% and 70%, respectively. Local progression was observed in 3 patients. Regional relapse occurred in 5 patients. Distant progression occurred in 10 patients. The 2-year overall survival (OS) and disease-free survival (DFS) were 57.5% and 36.6%, respectively. Radiation acute pneumonitis occurred as follows: three patients developed grade 1, two patients experienced grade 2 and one patient experienced grade 3 toxicity. Conclusion: Stereotactic body radiotherapy could have an alternative role in isolated loco-regional relapse in patients unfit or resistant to other therapies.

Original languageEnglish
Pages (from-to)1783-1790
Number of pages8
JournalAnticancer Research
Volume35
Issue number3
Publication statusPublished - Mar 1 2015

Keywords

  • Local control
  • Non-small cell lung cancer
  • Post-surgical recurrence
  • Salvage stereotactic radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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    Agolli, L., Valeriani, M., Carnevale, A., Falco, T., Bracci, S., De Sanctis, V., Minniti, G., Enrici, R. M., & Osti, M. F. (2015). Role of salvage stereotactic body radiation therapy in post-surgical loco-regional recurrence in a selected population of non-small cell lung cancer patients. Anticancer Research, 35(3), 1783-1790.