Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression

Raffaella Zanardi, Lorenzo Magri, David Rossini, Alessia Malaguti, Silvia Giordani, Cristina Lorenzi, Adele Pirovano, Enrico Smeraldi, Adelio Lucca

Research output: Contribution to journalArticle

Abstract

Transcranial magnetic stimulation (TMS) has been extensively studied as a treatment for Major Depression. However, no data are available about the role of genetic variables on the response to this treatment. We analysed the role of two polymorphisms that influence the response to antidepressants: the polymorphisms of the serotonin transporter promoter region (SERTPR) and of the 5-HT1A serotonergic receptor promoter region (-1019C/G). Ninety-nine patients from two double-blind, randomised, sham-controlled TMS trials were enrolled. There was a significant influence (p = 0.016) of the SERTPR polymorphism on treatment outcome, without differences between active and sham stimulation. Conversely, there was a significant (p = 0.014) interaction between 5-HT1A genotype and type of stimulation: C/C patients showed a higher difference between active and sham stimulation, indicating that these patients benefited more by TMS than C/G and G/G subjects. Our sample has not the power to control for the possible influence of different medications on these results.

Original languageEnglish
Pages (from-to)651-657
Number of pages7
JournalEuropean Neuropsychopharmacology
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 2007

Keywords

  • 5-HT
  • Depression
  • Polymorphism
  • Serotonin transporter
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)

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  • Cite this

    Zanardi, R., Magri, L., Rossini, D., Malaguti, A., Giordani, S., Lorenzi, C., Pirovano, A., Smeraldi, E., & Lucca, A. (2007). Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression. European Neuropsychopharmacology, 17(10), 651-657. https://doi.org/10.1016/j.euroneuro.2007.03.008