TY - JOUR
T1 - Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression
AU - Zanardi, Raffaella
AU - Magri, Lorenzo
AU - Rossini, David
AU - Malaguti, Alessia
AU - Giordani, Silvia
AU - Lorenzi, Cristina
AU - Pirovano, Adele
AU - Smeraldi, Enrico
AU - Lucca, Adelio
PY - 2007/10
Y1 - 2007/10
N2 - Transcranial magnetic stimulation (TMS) has been extensively studied as a treatment for Major Depression. However, no data are available about the role of genetic variables on the response to this treatment. We analysed the role of two polymorphisms that influence the response to antidepressants: the polymorphisms of the serotonin transporter promoter region (SERTPR) and of the 5-HT1A serotonergic receptor promoter region (-1019C/G). Ninety-nine patients from two double-blind, randomised, sham-controlled TMS trials were enrolled. There was a significant influence (p = 0.016) of the SERTPR polymorphism on treatment outcome, without differences between active and sham stimulation. Conversely, there was a significant (p = 0.014) interaction between 5-HT1A genotype and type of stimulation: C/C patients showed a higher difference between active and sham stimulation, indicating that these patients benefited more by TMS than C/G and G/G subjects. Our sample has not the power to control for the possible influence of different medications on these results.
AB - Transcranial magnetic stimulation (TMS) has been extensively studied as a treatment for Major Depression. However, no data are available about the role of genetic variables on the response to this treatment. We analysed the role of two polymorphisms that influence the response to antidepressants: the polymorphisms of the serotonin transporter promoter region (SERTPR) and of the 5-HT1A serotonergic receptor promoter region (-1019C/G). Ninety-nine patients from two double-blind, randomised, sham-controlled TMS trials were enrolled. There was a significant influence (p = 0.016) of the SERTPR polymorphism on treatment outcome, without differences between active and sham stimulation. Conversely, there was a significant (p = 0.014) interaction between 5-HT1A genotype and type of stimulation: C/C patients showed a higher difference between active and sham stimulation, indicating that these patients benefited more by TMS than C/G and G/G subjects. Our sample has not the power to control for the possible influence of different medications on these results.
KW - 5-HT
KW - Depression
KW - Polymorphism
KW - Serotonin transporter
KW - Transcranial magnetic stimulation
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U2 - 10.1016/j.euroneuro.2007.03.008
DO - 10.1016/j.euroneuro.2007.03.008
M3 - Article
C2 - 17466494
AN - SCOPUS:34547954315
VL - 17
SP - 651
EP - 657
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 10
ER -