TY - JOUR
T1 - Role of somatostatin and its analogues in gastrointestinal fistulas, ascites and pancreatic pseudocysts
AU - Bassi, C.
AU - Falconi, M.
AU - De Santis, L.
AU - Caldiron, E.
AU - Sartori, N.
AU - Pederzoli, P.
PY - 1994
Y1 - 1994
N2 - Naturally occurring somatostatin and, even more so, its analogue, octreotide, by virtue of its greater manageability, are used extensively today in various pancreatic and gastrointestinal disorders, where their potent secretion-inhibiting capacity is exploited. In a number of conditions such as pancreatic fistulas the beneficial efficacy of the hormone is now definitely established both for therapeutic and for prophylactic purposes, whereas, in the other disease areas analyzed here, its use appears to be as an adjuvant to more specific and more radical procedures. Future clarification as to indications, dosage regimens and treatment times may reveal more strictly curative uses of octreotide in its own right, though, even as things stand at present, its efficacy as a complementary measure is so self-evident as to prompt its inclusion in treatment schedules both for enterocutaneous fistulas and for ascites and pancreatic pseudocysts.
AB - Naturally occurring somatostatin and, even more so, its analogue, octreotide, by virtue of its greater manageability, are used extensively today in various pancreatic and gastrointestinal disorders, where their potent secretion-inhibiting capacity is exploited. In a number of conditions such as pancreatic fistulas the beneficial efficacy of the hormone is now definitely established both for therapeutic and for prophylactic purposes, whereas, in the other disease areas analyzed here, its use appears to be as an adjuvant to more specific and more radical procedures. Future clarification as to indications, dosage regimens and treatment times may reveal more strictly curative uses of octreotide in its own right, though, even as things stand at present, its efficacy as a complementary measure is so self-evident as to prompt its inclusion in treatment schedules both for enterocutaneous fistulas and for ascites and pancreatic pseudocysts.
KW - Ascites, pancreatic
KW - Fistulas, enterocutaneous
KW - Fistulas, pancreatic
KW - Octreotide
KW - Pseudocysts, pancreatic
KW - Somatostatin
UR - http://www.scopus.com/inward/record.url?scp=0028673128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028673128&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028673128
VL - 11
SP - 451
EP - 455
JO - Digestive Surgery
JF - Digestive Surgery
SN - 0253-4886
IS - 3-6
ER -