Role of stereotactic body radiation therapy for lung metastases from radio-resistant primary tumours

Research output: Contribution to journalArticle

Abstract

© 2017, Springer-Verlag Berlin Heidelberg. Objectives: A retrospective analysis was performed on patients treated for lung oligo-metastatic disease from radio-resistant histology groups. Methods: The primary end point was local control (LC), secondary end points were overall survival (OS) and progression free survival (PFS). Toxicity was scored according to CTCAE 4.03. Results: 200 patients were analyzed: 49.5% of the cases derived from colorectal primary tumors, 20.5% from sarcomas, 12.0% from renal cell carcinoma and the rest from other mixed origin. The mean follow-up was 24.2 months. LC at 1 and 2 years was 91, 84.9%. Primary histology and the presence of extra-pulmonary disease had a significant impact on LC. OS at 1 and 2 years was 88.7, 65.4%. Primary histology, disease free interval, presence of extra-pulmonary disease, number of irradiated lung lesions and age showed a correlation with prognosis at univariate analysis. PFS at 1 and 2 years was 84, 57.7%. The presence of extra-pulmonary disease and the number of irradiated lung lesions correlated with prognosis. Treatment was well tolerated with no G3–4 acute or late toxicity recorded. Conclusion: Colorectal metastases showed a higher rate of local relapse. However, the factors mostly influencing prognosis were the presence of extra-pulmonary disease and the number of lung lesions.
Original languageEnglish
Pages (from-to)1293-1299
Number of pages7
JournalJournal of Cancer Research and Clinical Oncology
Volume143
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Radio
Lung Diseases
Radiotherapy
Neoplasm Metastasis
Lung
Histology
Disease-Free Survival
Neoplasms
Survival
Berlin
Renal Cell Carcinoma
Sarcoma
Colorectal Neoplasms
Recurrence
Therapeutics

Keywords

  • Lung
  • Radio-resistant histology
  • SBRT

Cite this

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title = "Role of stereotactic body radiation therapy for lung metastases from radio-resistant primary tumours",
abstract = "{\circledC} 2017, Springer-Verlag Berlin Heidelberg. Objectives: A retrospective analysis was performed on patients treated for lung oligo-metastatic disease from radio-resistant histology groups. Methods: The primary end point was local control (LC), secondary end points were overall survival (OS) and progression free survival (PFS). Toxicity was scored according to CTCAE 4.03. Results: 200 patients were analyzed: 49.5{\%} of the cases derived from colorectal primary tumors, 20.5{\%} from sarcomas, 12.0{\%} from renal cell carcinoma and the rest from other mixed origin. The mean follow-up was 24.2 months. LC at 1 and 2 years was 91, 84.9{\%}. Primary histology and the presence of extra-pulmonary disease had a significant impact on LC. OS at 1 and 2 years was 88.7, 65.4{\%}. Primary histology, disease free interval, presence of extra-pulmonary disease, number of irradiated lung lesions and age showed a correlation with prognosis at univariate analysis. PFS at 1 and 2 years was 84, 57.7{\%}. The presence of extra-pulmonary disease and the number of irradiated lung lesions correlated with prognosis. Treatment was well tolerated with no G3–4 acute or late toxicity recorded. Conclusion: Colorectal metastases showed a higher rate of local relapse. However, the factors mostly influencing prognosis were the presence of extra-pulmonary disease and the number of lung lesions.",
keywords = "Lung, Radio-resistant histology, SBRT",
author = "Davide Franceschini and Luca Cozzi and Luca Cozzi and {De Rose}, Fiorenza and Piera Navarria and Ciro Franzese and Tiziana Comito and Cristina Iftode and Angelo Tozzi and {Di Brina}, Lucia and Ascolese, {Anna Maria} and Elena Clerici and Giuseppe D’Agostino and Antonella Fogliata and Marta Scorsetti and Marta Scorsetti",
year = "2017",
month = "7",
day = "1",
doi = "10.1007/s00432-017-2373-y",
language = "English",
volume = "143",
pages = "1293--1299",
journal = "Journal of Cancer Research and Clinical Oncology",
issn = "0171-5216",
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TY - JOUR

T1 - Role of stereotactic body radiation therapy for lung metastases from radio-resistant primary tumours

AU - Franceschini, Davide

AU - Cozzi, Luca

AU - Cozzi, Luca

AU - De Rose, Fiorenza

AU - Navarria, Piera

AU - Franzese, Ciro

AU - Comito, Tiziana

AU - Iftode, Cristina

AU - Tozzi, Angelo

AU - Di Brina, Lucia

AU - Ascolese, Anna Maria

AU - Clerici, Elena

AU - D’Agostino, Giuseppe

AU - Fogliata, Antonella

AU - Scorsetti, Marta

AU - Scorsetti, Marta

PY - 2017/7/1

Y1 - 2017/7/1

N2 - © 2017, Springer-Verlag Berlin Heidelberg. Objectives: A retrospective analysis was performed on patients treated for lung oligo-metastatic disease from radio-resistant histology groups. Methods: The primary end point was local control (LC), secondary end points were overall survival (OS) and progression free survival (PFS). Toxicity was scored according to CTCAE 4.03. Results: 200 patients were analyzed: 49.5% of the cases derived from colorectal primary tumors, 20.5% from sarcomas, 12.0% from renal cell carcinoma and the rest from other mixed origin. The mean follow-up was 24.2 months. LC at 1 and 2 years was 91, 84.9%. Primary histology and the presence of extra-pulmonary disease had a significant impact on LC. OS at 1 and 2 years was 88.7, 65.4%. Primary histology, disease free interval, presence of extra-pulmonary disease, number of irradiated lung lesions and age showed a correlation with prognosis at univariate analysis. PFS at 1 and 2 years was 84, 57.7%. The presence of extra-pulmonary disease and the number of irradiated lung lesions correlated with prognosis. Treatment was well tolerated with no G3–4 acute or late toxicity recorded. Conclusion: Colorectal metastases showed a higher rate of local relapse. However, the factors mostly influencing prognosis were the presence of extra-pulmonary disease and the number of lung lesions.

AB - © 2017, Springer-Verlag Berlin Heidelberg. Objectives: A retrospective analysis was performed on patients treated for lung oligo-metastatic disease from radio-resistant histology groups. Methods: The primary end point was local control (LC), secondary end points were overall survival (OS) and progression free survival (PFS). Toxicity was scored according to CTCAE 4.03. Results: 200 patients were analyzed: 49.5% of the cases derived from colorectal primary tumors, 20.5% from sarcomas, 12.0% from renal cell carcinoma and the rest from other mixed origin. The mean follow-up was 24.2 months. LC at 1 and 2 years was 91, 84.9%. Primary histology and the presence of extra-pulmonary disease had a significant impact on LC. OS at 1 and 2 years was 88.7, 65.4%. Primary histology, disease free interval, presence of extra-pulmonary disease, number of irradiated lung lesions and age showed a correlation with prognosis at univariate analysis. PFS at 1 and 2 years was 84, 57.7%. The presence of extra-pulmonary disease and the number of irradiated lung lesions correlated with prognosis. Treatment was well tolerated with no G3–4 acute or late toxicity recorded. Conclusion: Colorectal metastases showed a higher rate of local relapse. However, the factors mostly influencing prognosis were the presence of extra-pulmonary disease and the number of lung lesions.

KW - Lung

KW - Radio-resistant histology

KW - SBRT

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