Abstract
Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Cancer Investigation |
| DOIs | |
| Publication status | Accepted/In press - Jun 24 2016 |
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Keywords
- Abdominal metastases
- flattening filter-free beams
- RapidArc
- volumetric-modulated arc therapy
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases. / Franzese, Ciro; Cozzi, Luca; Franceschini, Davide; D'Agostino, Giuseppe; Comito, Tiziana; De Rose, Fiorenza; Navarria, Pierina; Mancosu, Pietro; Tomatis, Stefano; Fogliata, Antonella; Scorsetti, Marta.
In: Cancer Investigation, 24.06.2016, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases
AU - Franzese, Ciro
AU - Cozzi, Luca
AU - Franceschini, Davide
AU - D'Agostino, Giuseppe
AU - Comito, Tiziana
AU - De Rose, Fiorenza
AU - Navarria, Pierina
AU - Mancosu, Pietro
AU - Tomatis, Stefano
AU - Fogliata, Antonella
AU - Scorsetti, Marta
PY - 2016/6/24
Y1 - 2016/6/24
N2 - Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.
AB - Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.
KW - Abdominal metastases
KW - flattening filter-free beams
KW - RapidArc
KW - volumetric-modulated arc therapy
UR - http://www.scopus.com/inward/record.url?scp=84978468763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978468763&partnerID=8YFLogxK
U2 - 10.1080/07357907.2016.1197235
DO - 10.1080/07357907.2016.1197235
M3 - Article
AN - SCOPUS:84978468763
SP - 1
EP - 7
JO - Cancer Investigation
JF - Cancer Investigation
SN - 0735-7907
ER -