Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases

Ciro Franzese; Luca Cozzi; Davide Franceschini; Giuseppe D'Agostino; Tiziana Comito; Fiorenza De Rose; Pierina Navarria; Pietro Mancosu; Stefano Tomatis; Antonella Fogliata; Marta Scorsetti

doi:10.1080/07357907.2016.1197235

Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases

Ciro Franzese, Luca Cozzi, Davide Franceschini, Giuseppe D'Agostino, Tiziana Comito, Fiorenza De Rose, Pierina Navarria, Pietro Mancosu, Stefano Tomatis, Antonella Fogliata, Marta Scorsetti

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Cancer Investigation
DOIs	https://doi.org/10.1080/07357907.2016.1197235
Publication status	Accepted/In press - Jun 24 2016

Keywords

Abdominal metastases
flattening filter-free beams
RapidArc
volumetric-modulated arc therapy

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1080/07357907.2016.1197235

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Franzese, C., Cozzi, L., Franceschini, D., D'Agostino, G., Comito, T., De Rose, F., Navarria, P., Mancosu, P., Tomatis, S., Fogliata, A., & Scorsetti, M. (Accepted/In press). Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases. Cancer Investigation, 1-7. https://doi.org/10.1080/07357907.2016.1197235

Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases. / Franzese, Ciro; Cozzi, Luca; Franceschini, Davide ; D'Agostino, Giuseppe ; Comito, Tiziana; De Rose, Fiorenza; Navarria, Pierina ; Mancosu, Pietro ; Tomatis, Stefano; Fogliata, Antonella; Scorsetti, Marta.

In: Cancer Investigation, 24.06.2016, p. 1-7.

Research output: Contribution to journal › Article › peer-review

Franzese, C, Cozzi, L, Franceschini, D , D'Agostino, G , Comito, T, De Rose, F, Navarria, P , Mancosu, P , Tomatis, S, Fogliata, A & Scorsetti, M 2016, 'Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases', Cancer Investigation, pp. 1-7. https://doi.org/10.1080/07357907.2016.1197235

Franzese, Ciro ; Cozzi, Luca ; Franceschini, Davide ; D'Agostino, Giuseppe ; Comito, Tiziana ; De Rose, Fiorenza ; Navarria, Pierina ; Mancosu, Pietro ; Tomatis, Stefano ; Fogliata, Antonella ; Scorsetti, Marta. / Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases. In: Cancer Investigation. 2016 ; pp. 1-7.

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abstract = "Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.",

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author = "Ciro Franzese and Luca Cozzi and Davide Franceschini and Giuseppe D'Agostino and Tiziana Comito and {De Rose}, Fiorenza and Pierina Navarria and Pietro Mancosu and Stefano Tomatis and Antonella Fogliata and Marta Scorsetti",

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AU - Cozzi, Luca

AU - Franceschini, Davide

AU - D'Agostino, Giuseppe

AU - Comito, Tiziana

AU - De Rose, Fiorenza

AU - Navarria, Pierina

AU - Mancosu, Pietro

AU - Tomatis, Stefano

AU - Fogliata, Antonella

AU - Scorsetti, Marta

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AB - Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.

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KW - flattening filter-free beams

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Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases

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Keywords

ASJC Scopus subject areas

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