Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases

Ciro Franzese; Luca Cozzi; Davide Franceschini; Giuseppe D'Agostino; Tiziana Comito; Fiorenza De Rose; Pierina Navarria; Pietro Mancosu; Stefano Tomatis; Antonella Fogliata; Marta Scorsetti

doi:10.1080/07357907.2016.1197235

Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases

Ciro Franzese, Luca Cozzi, Davide Franceschini, Giuseppe D'Agostino, Tiziana Comito, Fiorenza De Rose, Pierina Navarria, Pietro Mancosu, Stefano Tomatis, Antonella Fogliata, Marta Scorsetti

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Cancer Investigation
DOIs	https://doi.org/10.1080/07357907.2016.1197235
Publication status	Accepted/In press - Jun 24 2016

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Keywords

Abdominal metastases
flattening filter-free beams
RapidArc
volumetric-modulated arc therapy

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

Franzese, C., Cozzi, L., Franceschini, D., D'Agostino, G., Comito, T., De Rose, F., Navarria, P., Mancosu, P., Tomatis, S., Fogliata, A., & Scorsetti, M. (Accepted/In press). Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases. Cancer Investigation, 1-7. https://doi.org/10.1080/07357907.2016.1197235

Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases. / Franzese, Ciro; Cozzi, Luca; Franceschini, Davide ; D'Agostino, Giuseppe ; Comito, Tiziana ; De Rose, Fiorenza ; Navarria, Pierina ; Mancosu, Pietro ; Tomatis, Stefano; Fogliata, Antonella; Scorsetti, Marta.

In: Cancer Investigation, 24.06.2016, p. 1-7.

Research output: Contribution to journal › Article

Franzese, C, Cozzi, L, Franceschini, D , D'Agostino, G , Comito, T , De Rose, F , Navarria, P , Mancosu, P , Tomatis, S, Fogliata, A & Scorsetti, M 2016, 'Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases', Cancer Investigation, pp. 1-7. https://doi.org/10.1080/07357907.2016.1197235

Franzese, Ciro ; Cozzi, Luca ; Franceschini, Davide ; D'Agostino, Giuseppe ; Comito, Tiziana ; De Rose, Fiorenza ; Navarria, Pierina ; Mancosu, Pietro ; Tomatis, Stefano ; Fogliata, Antonella ; Scorsetti, Marta. / Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases. In: Cancer Investigation. 2016 ; pp. 1-7.

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AU - Franceschini, Davide

AU - D'Agostino, Giuseppe

AU - Comito, Tiziana

AU - De Rose, Fiorenza

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AU - Fogliata, Antonella

AU - Scorsetti, Marta

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10.1080/07357907.2016.1197235