Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema

Alessandro Protti, Tommaso Maraffi, Marta Milesi, Emiliano Votta, Alessandro Santini, Paola Pugni, Davide T. Andreis, Francesco Nicosia, Emanuela Zannin, Stefano Gatti, Valentina Vaira, Stefano Ferrero, Luciano Gattinoni

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: Lungs behave as viscoelastic polymers. Harms of mechanical ventilation could then depend on not only amplitude (strain) but also velocity (strain rate) of lung deformation. Herein, we tested this hypothesis. DESIGN:: Laboratory investigation. SETTING:: Animal unit. SUBJECTS:: Thirty healthy piglets. INTERVENTIONS:: Two groups of animals were ventilated for 54 hours with matched lung strains (ratio between tidal volume and functional residual capacity) but different lung strain rates (ratio between strain and inspiratory time). Individual strains ranged between 0.6 and 3.5 in both groups. Piglets ventilated with low strain rates had an inspiratory-to-expiratory time ratio of 1:2–1:3. Those ventilated with high strain rates had much lower inspiratory-to-expiratory time ratios (down to 1:9). Respiratory rate was always 15 breaths/min. Lung viscoelastic behavior, with ventilator setting required per protocol, was “quantified” as dynamic respiratory system hysteresis (pressure-volume loop [in Joules]) and stress relaxation (airway pressure drop during an end-inspiratory pause [in cm H2O]). Primary outcome was the occurrence of pulmonary edema within 54 hours. MEASUREMENTS AND MAIN RESULTS:: On average, the two study groups were ventilated with well-matched strains (2.1 ± 0.9 vs 2.1 ± 0.9; p = 0.864) but different strain rates (1.8 ± 0.8 vs 4.6 ± 1.5 s; p <0.001), dynamic respiratory system hysteresis (0.6 ± 0.3 vs 1.4 ± 0.8 J; p = 0.001), and stress relaxation (3.1 ± 0.9 vs 5.0 ± 2.3 cm H2O; p = 0.008). The prevalence of pulmonary edema was 20% among piglets ventilated with low strain rates and 73% among those ventilated with high strain rates (p = 0.010). CONCLUSIONS:: High strain rate is a risk factor for ventilator-induced pulmonary edema, possibly because it amplifies lung viscoelastic behavior.

Original languageEnglish
Pages (from-to)e838-e845
Number of pages8
JournalCritical Care Medicine
Volume44
Issue number9
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema'. Together they form a unique fingerprint.

  • Cite this

    Protti, A., Maraffi, T., Milesi, M., Votta, E., Santini, A., Pugni, P., Andreis, D. T., Nicosia, F., Zannin, E., Gatti, S., Vaira, V., Ferrero, S., & Gattinoni, L. (2016). Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema. Critical Care Medicine, 44(9), e838-e845. https://doi.org/10.1097/CCM.0000000000001718