Role of stromal cells in neovascularization of multiple myeloma

Maria Fico, Giuseppe Mangialardi, Roberto Ria, Michele Moschetta, Domenico Ribatti, Angelo Vacca

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Angiogenesis plays a pivotal role in progression of both solid and hematologic tumors. We have focused on multiple myeloma (MM) and its bone marrow stromal cells which are not only a support for tumor cell survival, but also active inducers of angiogenesis by releasing a broad number of angiogenic cytokines. Also, stromal cells such as macrophages and mast cells can participate in blood vessels formation in MM through other processes, such as a vasculogenic mimicry. Finally, it has been discovered that hematopoietic stem and progenitor cells (HSPCs) are involved in the vasculogenesis of MM. Domenico Ribatti (Ed.) All rights reserved -

Original languageEnglish
Title of host publicationRecent Advances in Angiogenesis and Antiangiogenesis
PublisherBentham Science Publishers Ltd.
Pages80-84
Number of pages5
ISBN (Print)9781608056934
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Medicine(all)

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