TY - CHAP
T1 - Role of stromal cells in neovascularization of multiple myeloma
AU - Fico, Maria
AU - Mangialardi, Giuseppe
AU - Ria, Roberto
AU - Moschetta, Michele
AU - Ribatti, Domenico
AU - Vacca, Angelo
PY - 2009
Y1 - 2009
N2 - Angiogenesis plays a pivotal role in progression of both solid and hematologic tumors. We have focused on multiple myeloma (MM) and its bone marrow stromal cells which are not only a support for tumor cell survival, but also active inducers of angiogenesis by releasing a broad number of angiogenic cytokines. Also, stromal cells such as macrophages and mast cells can participate in blood vessels formation in MM through other processes, such as a vasculogenic mimicry. Finally, it has been discovered that hematopoietic stem and progenitor cells (HSPCs) are involved in the vasculogenesis of MM. Domenico Ribatti (Ed.) All rights reserved -
AB - Angiogenesis plays a pivotal role in progression of both solid and hematologic tumors. We have focused on multiple myeloma (MM) and its bone marrow stromal cells which are not only a support for tumor cell survival, but also active inducers of angiogenesis by releasing a broad number of angiogenic cytokines. Also, stromal cells such as macrophages and mast cells can participate in blood vessels formation in MM through other processes, such as a vasculogenic mimicry. Finally, it has been discovered that hematopoietic stem and progenitor cells (HSPCs) are involved in the vasculogenesis of MM. Domenico Ribatti (Ed.) All rights reserved -
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UR - http://www.scopus.com/inward/citedby.url?scp=84884465068&partnerID=8YFLogxK
U2 - 10.2174/9781608050048109010180
DO - 10.2174/9781608050048109010180
M3 - Chapter
AN - SCOPUS:84884465068
SN - 9781608056934
SP - 80
EP - 84
BT - Recent Advances in Angiogenesis and Antiangiogenesis
PB - Bentham Science Publishers Ltd.
ER -