TY - JOUR
T1 - Role of subcutaneous abdominal fat on cardiac function and proinflammatory cytokines in premenopausal obese women
AU - Marfella, Raffaele
AU - Grella, Roberto
AU - Rizzo, Maria Rosaria
AU - Barbieri, Michelangela
AU - Grella, Rodolfo
AU - Ferraraccio, Franca
AU - Cacciapuoti, Federico
AU - Mazzarella, Gennaro
AU - Ferraro, Nicola
AU - D'Andrea, Francesco
AU - Paolisso, Giuseppe
AU - Nicoletti, Gianfranco
PY - 2009/11
Y1 - 2009/11
N2 - The role of surgically removing subcutaneous fat by abdominoplasty on circulating inflammatory markers and myocardial dysfunction, evaluated by myocardial performance index (MPI), were investigated. Twenty volunteers submitted to the abdominoplasty (abdominoplasty group), and other 28 women treated by hypocaloric diet (diet group) were evaluated. Echocardiographic parameters of MPI, circulating levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6, were performed at baseline and 2 months later. Compared with nonobese women, obese women had increased concentrations of TNF-α (P <0.01), IL-6 (P <0.01), and higher MPI (P <0.02), indicating ventricular dysfunction. Subcutaneous fat concentrations of TNF-α and IL-6 were related to MPI impairment. After 60 days, waist-to hip ratio was significantly reduced in the abdominoplasty group. Anthropometric changes were accompanied by a significant decline in plasma concentrations of TNF-α and IL-6 levels as well as by significant improvements of MPI in abdominoplasty group compared with diet group. Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women.
AB - The role of surgically removing subcutaneous fat by abdominoplasty on circulating inflammatory markers and myocardial dysfunction, evaluated by myocardial performance index (MPI), were investigated. Twenty volunteers submitted to the abdominoplasty (abdominoplasty group), and other 28 women treated by hypocaloric diet (diet group) were evaluated. Echocardiographic parameters of MPI, circulating levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6, were performed at baseline and 2 months later. Compared with nonobese women, obese women had increased concentrations of TNF-α (P <0.01), IL-6 (P <0.01), and higher MPI (P <0.02), indicating ventricular dysfunction. Subcutaneous fat concentrations of TNF-α and IL-6 were related to MPI impairment. After 60 days, waist-to hip ratio was significantly reduced in the abdominoplasty group. Anthropometric changes were accompanied by a significant decline in plasma concentrations of TNF-α and IL-6 levels as well as by significant improvements of MPI in abdominoplasty group compared with diet group. Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women.
KW - Abdominoplastic surgery
KW - Cardiac function
KW - Inflammation
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U2 - 10.1097/SAP.0b013e3181955cdb
DO - 10.1097/SAP.0b013e3181955cdb
M3 - Article
C2 - 19806043
AN - SCOPUS:70350662797
VL - 63
SP - 490
EP - 495
JO - Annals of Plastic Surgery
JF - Annals of Plastic Surgery
SN - 0148-7043
IS - 5
ER -