Role of subcutaneous abdominal fat on cardiac function and proinflammatory cytokines in premenopausal obese women

Raffaele Marfella, Roberto Grella, Maria Rosaria Rizzo, Michelangela Barbieri, Rodolfo Grella, Franca Ferraraccio, Federico Cacciapuoti, Gennaro Mazzarella, Nicola Ferraro, Francesco D'Andrea, Giuseppe Paolisso, Gianfranco Nicoletti

Research output: Contribution to journalArticlepeer-review

Abstract

The role of surgically removing subcutaneous fat by abdominoplasty on circulating inflammatory markers and myocardial dysfunction, evaluated by myocardial performance index (MPI), were investigated. Twenty volunteers submitted to the abdominoplasty (abdominoplasty group), and other 28 women treated by hypocaloric diet (diet group) were evaluated. Echocardiographic parameters of MPI, circulating levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6, were performed at baseline and 2 months later. Compared with nonobese women, obese women had increased concentrations of TNF-α (P <0.01), IL-6 (P <0.01), and higher MPI (P <0.02), indicating ventricular dysfunction. Subcutaneous fat concentrations of TNF-α and IL-6 were related to MPI impairment. After 60 days, waist-to hip ratio was significantly reduced in the abdominoplasty group. Anthropometric changes were accompanied by a significant decline in plasma concentrations of TNF-α and IL-6 levels as well as by significant improvements of MPI in abdominoplasty group compared with diet group. Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women.

Original languageEnglish
Pages (from-to)490-495
Number of pages6
JournalAnnals of Plastic Surgery
Volume63
Issue number5
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Abdominoplastic surgery
  • Cardiac function
  • Inflammation

ASJC Scopus subject areas

  • Surgery

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