Role of [18F]-FDG PET in patients with atypical parkinsonism associated with dementia

Stefano Raffa, Maria Isabella Donegani, Anna Borra, Alberto Miceli, Michele Balma, Matteo Bauckneht, Silvia Morbelli

Research output: Contribution to journalReview articlepeer-review


Purpose: The present review aims to discuss indications for the use of [18F]-FDG PET in patients with APS associated with dementia as emerged in the EANM/EAN joint recommendations for its use in dementia. New lines of evidence emerged after the EANM/EAN consensus have here been systematically reviewed. Methods: We searched in the databases PubMed, PMC, Google Scholar, Medline using as text “positron emission tomography—PET”, “PET/CT”, “MR” and “Parkinsonian Syndromes”, “Atypical Parkinsonism”, “progressive supranuclear palsy”, “cortico-basal syndrome”, “dementia with Lewy Bodies”. We selected only PET studies or multimodal imaging studies including the use of [18F]-FDG PET. Results: Atypical parkinsonian syndromes (APS) associated with dementia are complex clinical scenarios including progressive supranuclear palsy (PSP), corticobasal syndrome/degeneration (CBS/CBD) and dementia with Lewy bodies (DLB). The clinical diagnosis of these diseases is often challenging and has relevant repercussions for patients’ management and prognosis. A systematic review of the articles published between December 2015 and December 2019 (so after the deadline of the literature search at the time of the EAN/EANM recommendations) was carried out. A total of further 18 papers met our inclusion criteria. Conclusion: Although available studies in patients with APS and dementia suffer from methodological limitations, the expert consensus emerged from the EANM/EAN recommendations was in favor of its use for specific clinical questions in these group of patients. Studies in a larger number of patients published after the publication of the joint recommendations have further supported the use of 18F-FDG PET in patients with APS associated with dementia.

Original languageEnglish
JournalClinical and Translational Imaging
Publication statusAccepted/In press - Jan 1 2020


  • Atypical parkinsonian syndromes
  • Brain [f]-FDG PET
  • Dementia
  • Neurodegenerative parkinsonism

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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