Abstract
This article will review the role of the sympathetic nervous system in the pathogenesis of metabolic syndrome and sleep apnea and the pathophysiological link between these two clinical conditions. Several indices of adrenergic tone have all shown an increase in the different conditions clustering in the metabolic syndrome. The adrenergic overdrive appears to be potentiated in the metabolic syndrome and contributes at the cardiovascular, structural, and functional alterations typical of this condition. Several mechanisms, supporting the hyperadrenergic state in metabolic syndrome, are also present in another pathophysiological condition, such as obstructive sleep apnea, which contributes to determining the increased cardiovascular risk of these patients. The data reviewed herein support the relevance of the sympathetic nervous system in the pathogenesis of the metabolic syndrome and sleep apnea and highlight the importance of the sympathomodulation as a specific aim of therapeutic intervention to reduce the cardiovascular risk and the morbidity of these pathophysiological conditions.
| Original language | English |
|---|---|
| Title of host publication | Modulation of Sleep by Obesity, Diabetes, Age, and Diet |
| Publisher | Elsevier Inc. |
| Pages | 165-175 |
| Number of pages | 11 |
| ISBN (Print) | 9780124202405, 9780124201682 |
| DOIs | |
| Publication status | Published - Sep 15 2014 |
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Keywords
- Adrenergic modulation
- Cardiovascular risk
- Metabolic syndrome
- Reflex mechanisms
- Sleep apnea
- Sympathetic nervous system
ASJC Scopus subject areas
- Medicine(all)
Cite this
Role of Sympathetic Nervous System in the Metabolic Syndrome and Sleep Apnea. / Seravalle, Gino; Grassi, Guido.
Modulation of Sleep by Obesity, Diabetes, Age, and Diet. Elsevier Inc., 2014. p. 165-175.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Role of Sympathetic Nervous System in the Metabolic Syndrome and Sleep Apnea
AU - Seravalle, Gino
AU - Grassi, Guido
PY - 2014/9/15
Y1 - 2014/9/15
N2 - This article will review the role of the sympathetic nervous system in the pathogenesis of metabolic syndrome and sleep apnea and the pathophysiological link between these two clinical conditions. Several indices of adrenergic tone have all shown an increase in the different conditions clustering in the metabolic syndrome. The adrenergic overdrive appears to be potentiated in the metabolic syndrome and contributes at the cardiovascular, structural, and functional alterations typical of this condition. Several mechanisms, supporting the hyperadrenergic state in metabolic syndrome, are also present in another pathophysiological condition, such as obstructive sleep apnea, which contributes to determining the increased cardiovascular risk of these patients. The data reviewed herein support the relevance of the sympathetic nervous system in the pathogenesis of the metabolic syndrome and sleep apnea and highlight the importance of the sympathomodulation as a specific aim of therapeutic intervention to reduce the cardiovascular risk and the morbidity of these pathophysiological conditions.
AB - This article will review the role of the sympathetic nervous system in the pathogenesis of metabolic syndrome and sleep apnea and the pathophysiological link between these two clinical conditions. Several indices of adrenergic tone have all shown an increase in the different conditions clustering in the metabolic syndrome. The adrenergic overdrive appears to be potentiated in the metabolic syndrome and contributes at the cardiovascular, structural, and functional alterations typical of this condition. Several mechanisms, supporting the hyperadrenergic state in metabolic syndrome, are also present in another pathophysiological condition, such as obstructive sleep apnea, which contributes to determining the increased cardiovascular risk of these patients. The data reviewed herein support the relevance of the sympathetic nervous system in the pathogenesis of the metabolic syndrome and sleep apnea and highlight the importance of the sympathomodulation as a specific aim of therapeutic intervention to reduce the cardiovascular risk and the morbidity of these pathophysiological conditions.
KW - Adrenergic modulation
KW - Cardiovascular risk
KW - Metabolic syndrome
KW - Reflex mechanisms
KW - Sleep apnea
KW - Sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=84945986958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945986958&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-420168-2.00018-1
DO - 10.1016/B978-0-12-420168-2.00018-1
M3 - Chapter
AN - SCOPUS:84945986958
SN - 9780124202405
SN - 9780124201682
SP - 165
EP - 175
BT - Modulation of Sleep by Obesity, Diabetes, Age, and Diet
PB - Elsevier Inc.
ER -