Abstract
Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.
| Original language | English |
|---|---|
| Pages (from-to) | 217-223 |
| Number of pages | 7 |
| Journal | Clinical & Experimental Metastasis |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Extracellular matrix
- Integrins
- Invasion
- Metastasis
ASJC Scopus subject areas
- Cancer Research
Cite this
Role of the α3β1 and α6β4 integrins in tumor invasion. / Giannelli, Gianluigi; Astigiano, Simonetta; Antonaci, Salvatore; Morini, Monica; Barbieri, Ottavia; Noonan, Douglas M.; Albini, Adriana.
In: Clinical & Experimental Metastasis, Vol. 19, No. 3, 2002, p. 217-223.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of the α3β1 and α6β4 integrins in tumor invasion
AU - Giannelli, Gianluigi
AU - Astigiano, Simonetta
AU - Antonaci, Salvatore
AU - Morini, Monica
AU - Barbieri, Ottavia
AU - Noonan, Douglas M.
AU - Albini, Adriana
PY - 2002
Y1 - 2002
N2 - Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.
AB - Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.
KW - Extracellular matrix
KW - Integrins
KW - Invasion
KW - Metastasis
UR - http://www.scopus.com/inward/record.url?scp=0035983210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035983210&partnerID=8YFLogxK
U2 - 10.1023/A:1015579204607
DO - 10.1023/A:1015579204607
M3 - Article
C2 - 12067202
AN - SCOPUS:0035983210
VL - 19
SP - 217
EP - 223
JO - Clinical and Experimental Metastasis
JF - Clinical and Experimental Metastasis
SN - 0262-0898
IS - 3
ER -