Role of the α3β1 and α6β4 integrins in tumor invasion

Gianluigi Giannelli; Simonetta Astigiano; Salvatore Antonaci; Monica Morini; Ottavia Barbieri; Douglas M. Noonan; Adriana Albini

doi:10.1023/A:1015579204607

Role of the α3β1 and α6β4 integrins in tumor invasion

Gianluigi Giannelli, Simonetta Astigiano, Salvatore Antonaci, Monica Morini, Ottavia Barbieri, Douglas M. Noonan, Adriana Albini

Research output: Contribution to journal › Article › peer-review

Abstract

Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.

Original language	English
Pages (from-to)	217-223
Number of pages	7
Journal	Clinical & Experimental Metastasis
Volume	19
Issue number	3
DOIs	https://doi.org/10.1023/A:1015579204607
Publication status	Published - 2002

Keywords

Extracellular matrix
Integrins
Invasion
Metastasis

ASJC Scopus subject areas

Cancer Research

Access to Document

10.1023/A:1015579204607

Fingerprint Dive into the research topics of 'Role of the α3β1 and α6β4 integrins in tumor invasion'. Together they form a unique fingerprint.

Cite this

@article{0ab3336ff0ab4354b4a15cf707fb646b,

title = "Role of the α3β1 and α6β4 integrins in tumor invasion",

abstract = "Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.",

keywords = "Extracellular matrix, Integrins, Invasion, Metastasis",

author = "Gianluigi Giannelli and Simonetta Astigiano and Salvatore Antonaci and Monica Morini and Ottavia Barbieri and Noonan, {Douglas M.} and Adriana Albini",

year = "2002",

doi = "10.1023/A:1015579204607",

language = "English",

volume = "19",

pages = "217--223",

journal = "Clinical and Experimental Metastasis",

issn = "0262-0898",

publisher = "Springer Netherlands",

number = "3",

}

TY - JOUR

T1 - Role of the α3β1 and α6β4 integrins in tumor invasion

AU - Giannelli, Gianluigi

AU - Astigiano, Simonetta

AU - Antonaci, Salvatore

AU - Morini, Monica

AU - Barbieri, Ottavia

AU - Noonan, Douglas M.

AU - Albini, Adriana

PY - 2002

Y1 - 2002

N2 - Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.

AB - Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.

KW - Extracellular matrix

KW - Integrins

KW - Invasion

KW - Metastasis

UR - http://www.scopus.com/inward/record.url?scp=0035983210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035983210&partnerID=8YFLogxK

U2 - 10.1023/A:1015579204607

DO - 10.1023/A:1015579204607

M3 - Article

C2 - 12067202

AN - SCOPUS:0035983210

VL - 19

SP - 217

EP - 223

JO - Clinical and Experimental Metastasis

JF - Clinical and Experimental Metastasis

SN - 0262-0898

IS - 3

ER -