Role of the α3β1 and α6β4 integrins in tumor invasion

Gianluigi Giannelli, Simonetta Astigiano, Salvatore Antonaci, Monica Morini, Ottavia Barbieri, Douglas M. Noonan, Adriana Albini

Research output: Contribution to journalArticlepeer-review

Abstract

Integrin receptors are well-known mediators of cell adhesion that also have a fundamental role in controlling the migration of cells through tissues. Among the numerous members of a still growing family, two particular molecular complexes have turned out to be of key importance in tumor cell invasion of basement membranes, the α3β1 and α6β4 integrins. In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalClinical & Experimental Metastasis
Volume19
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Extracellular matrix
  • Integrins
  • Invasion
  • Metastasis

ASJC Scopus subject areas

  • Cancer Research

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