In the present study the role of amygdala in the antidepressant action of imipramine is discussed. An animal model of depression is induced, in rats, by systemic injection of low doses of apomorphine. Systemic administration of imipramine prevents, as already reported, apomorphine-induced sedation. The same effect is observed following intraamygdaloid imipramine administration. On the contrary, local injection of imipramine in frontal cortex or caudate nucleus does not affect apomorphine-induced sedation.
|Translated title of the contribution||Role of the amygdala in animal model of depression|
|Number of pages||4|
|Journal||Bollettino della Societa Italiana di Biologia Sperimentale|
|Publication status||Published - 1983|
ASJC Scopus subject areas