Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy

Sandra Mastroianno, Giuseppe Di Stolfo, Davide Seripa, Michele Antonio Pacilli, Giulia Paroni, Carlo Coli, Maria Urbano, Carmela D'Arienzo, Carolina Gravina, Domenico Rosario Potenza, Giovanni De Luca, Antonio Greco, Aldo Russo

Research output: Contribution to journalArticle

Abstract

Background Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis. Objectives To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease. Materials and methods 258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion. Results As compared with ϵ3/ϵ3, in ϵ4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total peripheral revascularization (22.64% vs. 5.06%; p < 0.001) was observed. Prospective analysis, showed that ϵ4-carriers have an increased hazard ratio for major adverse cardiovascular events (adjusted HR 1.829, 95% CI 1.017±3.287; p = 0.044) and total peripheral revascularization (adjusted HR = 5.916, 95% CI 2.405±14.554, p <0.001). Conclusions The ϵ4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.

Original languageEnglish
Article numbere0171055
JournalPLoS One
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 1 2017

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apolipoprotein E
Apolipoproteins E
prospective studies
Polymorphism
Italy
Lower Extremity
vascular diseases
genetic polymorphism
Prospective Studies
atherosclerosis
Atherosclerosis
Genotype
Peripheral Vascular Diseases
genotype
Physical vapor deposition
longitudinal studies
Vascular Diseases
blood vessels
Blood Vessels
Longitudinal Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Role of the APOE polymorphism in carotid and lower limb revascularization : A prospective study from Southern Italy. / Mastroianno, Sandra; Di Stolfo, Giuseppe; Seripa, Davide; Antonio Pacilli, Michele; Paroni, Giulia; Coli, Carlo; Urbano, Maria; D'Arienzo, Carmela; Gravina, Carolina; Rosario Potenza, Domenico; De Luca, Giovanni; Greco, Antonio; Russo, Aldo.

In: PLoS One, Vol. 12, No. 3, e0171055, 01.03.2017.

Research output: Contribution to journalArticle

Mastroianno, Sandra ; Di Stolfo, Giuseppe ; Seripa, Davide ; Antonio Pacilli, Michele ; Paroni, Giulia ; Coli, Carlo ; Urbano, Maria ; D'Arienzo, Carmela ; Gravina, Carolina ; Rosario Potenza, Domenico ; De Luca, Giovanni ; Greco, Antonio ; Russo, Aldo. / Role of the APOE polymorphism in carotid and lower limb revascularization : A prospective study from Southern Italy. In: PLoS One. 2017 ; Vol. 12, No. 3.
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abstract = "Background Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis. Objectives To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease. Materials and methods 258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion. Results As compared with ϵ3/ϵ3, in ϵ4-carriers a significant higher incidence of major adverse cardiovascular events (35.58{\%} vs. 20.79{\%}; p = 0.025) and total peripheral revascularization (22.64{\%} vs. 5.06{\%}; p < 0.001) was observed. Prospective analysis, showed that ϵ4-carriers have an increased hazard ratio for major adverse cardiovascular events (adjusted HR 1.829, 95{\%} CI 1.017±3.287; p = 0.044) and total peripheral revascularization (adjusted HR = 5.916, 95{\%} CI 2.405±14.554, p <0.001). Conclusions The ϵ4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.",
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T2 - A prospective study from Southern Italy

AU - Mastroianno, Sandra

AU - Di Stolfo, Giuseppe

AU - Seripa, Davide

AU - Antonio Pacilli, Michele

AU - Paroni, Giulia

AU - Coli, Carlo

AU - Urbano, Maria

AU - D'Arienzo, Carmela

AU - Gravina, Carolina

AU - Rosario Potenza, Domenico

AU - De Luca, Giovanni

AU - Greco, Antonio

AU - Russo, Aldo

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N2 - Background Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis. Objectives To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease. Materials and methods 258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion. Results As compared with ϵ3/ϵ3, in ϵ4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total peripheral revascularization (22.64% vs. 5.06%; p < 0.001) was observed. Prospective analysis, showed that ϵ4-carriers have an increased hazard ratio for major adverse cardiovascular events (adjusted HR 1.829, 95% CI 1.017±3.287; p = 0.044) and total peripheral revascularization (adjusted HR = 5.916, 95% CI 2.405±14.554, p <0.001). Conclusions The ϵ4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.

AB - Background Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis. Objectives To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease. Materials and methods 258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion. Results As compared with ϵ3/ϵ3, in ϵ4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total peripheral revascularization (22.64% vs. 5.06%; p < 0.001) was observed. Prospective analysis, showed that ϵ4-carriers have an increased hazard ratio for major adverse cardiovascular events (adjusted HR 1.829, 95% CI 1.017±3.287; p = 0.044) and total peripheral revascularization (adjusted HR = 5.916, 95% CI 2.405±14.554, p <0.001). Conclusions The ϵ4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.

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