Role of the autonomic nervous system in the genesis of first and second degree atrio-ventricular nodal block

P. Alboni, R. Pirani, N. Paparella, R. Cappato, S. Preziosi, A. M. Tomasi

Research output: Contribution to journalArticle

Abstract

Thirty-four patients with a prolonged A-H interval (group I) and 26 with A-V nodal Wenckebach block (group II) were studied in the basal state and after autonomic blockade (propranolol 0.2 mg kg-1 and atropine 0.04 mg kg-1 in order to assess the role of autonomic system in A-V nodal conduction disturbances. In group I, the A-H intervals did not change significantly after autonomic blockade, whereas pacing cycle length for Wenckebach block, effective and functional refractory periods of the A-V node decreased significantly (P <0.05). In the 22 patients with organic heart disease these variables did not change significantly after autonomic blockade, whereas in the 12 without underlying heart disease, they decreased in all cases (P <0.001). In the former, the variables of intrinsic A-V nodal conduction were normal in only 9% of patients, whereas in the latter they were normal in 66%. Also in group II, the intrinsic A-H intervals were normal in only 6% of patients with cardiac disease but were normal in 63% without underlying heart disease. These data suggest that in the patients with first and second degree A-V nodal block and organic heart disease, the conduction disturbance is predominantly related to intrinsic involvement of A-V node, whereas in the subjects without underlying heart disease the A-V nodal blocks appear mainly related to autonomic alterations.

Original languageEnglish
Pages (from-to)952-960
Number of pages9
JournalEuropean Heart Journal
Volume7
Issue number11
Publication statusPublished - 1986

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Autonomic Nervous System
Neurology
Heart Diseases
Conduction
Atrioventricular Node
Interval
Disturbance
Cycle Length
Vertex of a graph
Atropine
Propranolol
Cardiac
Refractory materials
Heart disease
Heart
Intrinsic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Cite this

Alboni, P., Pirani, R., Paparella, N., Cappato, R., Preziosi, S., & Tomasi, A. M. (1986). Role of the autonomic nervous system in the genesis of first and second degree atrio-ventricular nodal block. European Heart Journal, 7(11), 952-960.

Role of the autonomic nervous system in the genesis of first and second degree atrio-ventricular nodal block. / Alboni, P.; Pirani, R.; Paparella, N.; Cappato, R.; Preziosi, S.; Tomasi, A. M.

In: European Heart Journal, Vol. 7, No. 11, 1986, p. 952-960.

Research output: Contribution to journalArticle

Alboni, P, Pirani, R, Paparella, N, Cappato, R, Preziosi, S & Tomasi, AM 1986, 'Role of the autonomic nervous system in the genesis of first and second degree atrio-ventricular nodal block', European Heart Journal, vol. 7, no. 11, pp. 952-960.
Alboni, P. ; Pirani, R. ; Paparella, N. ; Cappato, R. ; Preziosi, S. ; Tomasi, A. M. / Role of the autonomic nervous system in the genesis of first and second degree atrio-ventricular nodal block. In: European Heart Journal. 1986 ; Vol. 7, No. 11. pp. 952-960.
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