Role of the B-cell receptor in chronic lymphocytic leukemia: Where do we stand?

Franco Fais, Silvia Bruno, Fabio Ghiotto

Research output: Contribution to journalArticle


The past 15 years have witnessed an enormous effort in studying Bcell Chronic Lymphocytic Leukemia. A great number of researches brought significant novel information and a better understanding of the natural history of this disease. This mini review will focus on the studies related to the Immunoglobulin variable (IgV) genes rearrangements that compose the Bcell receptor (BcR) of the leukemic clones. These studies have defined a role for the antigen(s) in the paths that lead to leukemic clone generation/expansion and underscore the informative value represented by BcR analyses.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalItalian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia
Issue number1-2
Publication statusPublished - 2010



  • Antigen stimulation
  • Chronic Lymphocytic Leukemia
  • Immunoglobulin Variable Region

ASJC Scopus subject areas

  • Anatomy
  • Embryology

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