Role of the efferent arteriole in glomerular hemodynamics of superficial nephrons

V. E. Andreucci, A. Dal Canton, A. Corradi, R. Stanziale, L. Migone

Research output: Contribution to journalArticlepeer-review

Abstract

Hemodynamic pressure in glomerular capillaries (GCP) and in first order peritubular capillaries (EAP) in superficial nephrons of mutant Wistar rats with surface glomeruli was measured by micropuncture with a servo nulling device in the following conditions: control; norepinephrine infusion (NE); epinephrine infusion (E); dopamine infusion (D); hemorrhagic hypotension (HH); HH + NE; HH + E; HH + D; acute hypertension secondary to bilateral cervical vagotomy and occlusion of both common carotid arteries. BP was also recorded. Both GCP/BP and EAP/GCP ratios averaged 0.40 in control conditions, but only the EAP/GCP ratio remained constant in all conditions under study, indicating that approximately 60% of the hydrostatic pressure in glomerular capillaries is constantly dissipated by the efferent arteriole. When all values of EAP were plotted against the respective values of GCP, a linear relationship was detected (r = 0.843). These results indicate that changes of pressure in the first order peritubular capillaries of superficial nephrons are merely secondary to changes in glomerular capillary pressure.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalKidney International
Volume9
Issue number6
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Nephrology

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