TY - JOUR
T1 - Role of the EGF +61A>G polymorphism in melanoma pathogenesis
T2 - an experience on a large series of Italian cases and controls.
AU - Casula, Milena
AU - Alaibac, Mauro
AU - Pizzichetta, Maria A.
AU - Bono, Riccardo
AU - Ascierto, Paolo A.
AU - Stanganelli, Ignazio
AU - Canzanella, Sergio
AU - Palomba, Grazia
AU - Zattra, Edoardo
AU - Palmieri, Giuseppe
PY - 2009
Y1 - 2009
N2 - BACKGROUND: A single nucleotide polymorphism (61A>G) in the epidermal growth factor (EGF) gene has been implicated in both melanoma pathogenesis and increased melanoma risk. To further evaluate this association, we conducted a case-control study in a clinic-based Italian population. METHODS: Individuals with less than 10 (N = 127) or more than 100 (N = 128) benign nevi, and patients with cutaneous melanoma (N = 418) were investigated for the EGF +61A>G polymorphism, using an automated sequencing approach. RESULTS: Overall, no difference in EGF genotype frequencies was observed among subjects with different number of nevi as well as when non-melanoma healthy controls were compared with the melanoma patients. However, a heterogeneous distribution of the frequencies of the G/G genotype was detected among cases and controls originating from North Italy (21.1 and 18.3%, respectively) vs. those from South Italy (12.6 and 17.1%, respectively). CONCLUSION: Our findings further suggest that EGF +61A>G polymorphism may have a limited impact on predisposition and/or pathogenesis of melanoma and its prevalence may vary in different populations.
AB - BACKGROUND: A single nucleotide polymorphism (61A>G) in the epidermal growth factor (EGF) gene has been implicated in both melanoma pathogenesis and increased melanoma risk. To further evaluate this association, we conducted a case-control study in a clinic-based Italian population. METHODS: Individuals with less than 10 (N = 127) or more than 100 (N = 128) benign nevi, and patients with cutaneous melanoma (N = 418) were investigated for the EGF +61A>G polymorphism, using an automated sequencing approach. RESULTS: Overall, no difference in EGF genotype frequencies was observed among subjects with different number of nevi as well as when non-melanoma healthy controls were compared with the melanoma patients. However, a heterogeneous distribution of the frequencies of the G/G genotype was detected among cases and controls originating from North Italy (21.1 and 18.3%, respectively) vs. those from South Italy (12.6 and 17.1%, respectively). CONCLUSION: Our findings further suggest that EGF +61A>G polymorphism may have a limited impact on predisposition and/or pathogenesis of melanoma and its prevalence may vary in different populations.
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U2 - 10.1186/1471-5945-9-7
DO - 10.1186/1471-5945-9-7
M3 - Article
C2 - 19624835
AN - SCOPUS:69449096559
VL - 9
SP - 7
JO - BMC Dermatology
JF - BMC Dermatology
SN - 1471-5945
ER -