Role of the Genetic Study in the Management of Carotid Body Tumor in Paraganglioma Syndrome

M. Antonello, M. Piazza, M. Menegolo, G. Opocher, G. P. Deriu, F. Grego

Research output: Contribution to journalArticle

Abstract

Diagnosis of carotid body tumor (CBT) was made in a 36 years old woman. The pre-operative examination included genetic analysis of the succinate dehydrogenase that showed a mutation in his subunit D responsible of multiple paraganglioma at slow growth. Subsequently a thoraco-abdominal CT and indium111 octreotide body scan were performed and another paraganglioma was detected in the anterior mediastinum. CBT was surgically removed; differently the thoracic lesion due to his benign genetic profile was not treated. During a 3-years follow-up the thoracic paraganglioma as expected, didn't increase. Genetic analysis of succinate dehydrogenase, should be performed in the management of CBT.

Original languageEnglish
Pages (from-to)517-519
Number of pages3
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume36
Issue number5
DOIs
Publication statusPublished - Nov 2008

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Keywords

  • Carotid body tumor
  • Paraganglioma
  • Succinate dehydrogenase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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