Role of the Genetic Study in the Management of Carotid Body Tumor in Paraganglioma Syndrome

M. Antonello; M. Piazza; M. Menegolo; G. Opocher; G. P. Deriu; F. Grego

doi:10.1016/j.ejvs.2008.06.021

Role of the Genetic Study in the Management of Carotid Body Tumor in Paraganglioma Syndrome

M. Antonello, M. Piazza, M. Menegolo, G. Opocher, G. P. Deriu, F. Grego

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Diagnosis of carotid body tumor (CBT) was made in a 36 years old woman. The pre-operative examination included genetic analysis of the succinate dehydrogenase that showed a mutation in his subunit D responsible of multiple paraganglioma at slow growth. Subsequently a thoraco-abdominal CT and indium¹¹¹ octreotide body scan were performed and another paraganglioma was detected in the anterior mediastinum. CBT was surgically removed; differently the thoracic lesion due to his benign genetic profile was not treated. During a 3-years follow-up the thoracic paraganglioma as expected, didn't increase. Genetic analysis of succinate dehydrogenase, should be performed in the management of CBT.

Original language	English
Pages (from-to)	517-519
Number of pages	3
Journal	European Journal of Vascular and Endovascular Surgery
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/j.ejvs.2008.06.021
Publication status	Published - Nov 2008

Keywords

Carotid body tumor
Paraganglioma
Succinate dehydrogenase

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Surgery

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title = "Role of the Genetic Study in the Management of Carotid Body Tumor in Paraganglioma Syndrome",

abstract = "Diagnosis of carotid body tumor (CBT) was made in a 36 years old woman. The pre-operative examination included genetic analysis of the succinate dehydrogenase that showed a mutation in his subunit D responsible of multiple paraganglioma at slow growth. Subsequently a thoraco-abdominal CT and indium111 octreotide body scan were performed and another paraganglioma was detected in the anterior mediastinum. CBT was surgically removed; differently the thoracic lesion due to his benign genetic profile was not treated. During a 3-years follow-up the thoracic paraganglioma as expected, didn't increase. Genetic analysis of succinate dehydrogenase, should be performed in the management of CBT.",

keywords = "Carotid body tumor, Paraganglioma, Succinate dehydrogenase",

author = "M. Antonello and M. Piazza and M. Menegolo and G. Opocher and Deriu, {G. P.} and F. Grego",

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AU - Antonello, M.

AU - Piazza, M.

AU - Menegolo, M.

AU - Opocher, G.

AU - Deriu, G. P.

AU - Grego, F.

PY - 2008/11

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N2 - Diagnosis of carotid body tumor (CBT) was made in a 36 years old woman. The pre-operative examination included genetic analysis of the succinate dehydrogenase that showed a mutation in his subunit D responsible of multiple paraganglioma at slow growth. Subsequently a thoraco-abdominal CT and indium111 octreotide body scan were performed and another paraganglioma was detected in the anterior mediastinum. CBT was surgically removed; differently the thoracic lesion due to his benign genetic profile was not treated. During a 3-years follow-up the thoracic paraganglioma as expected, didn't increase. Genetic analysis of succinate dehydrogenase, should be performed in the management of CBT.

AB - Diagnosis of carotid body tumor (CBT) was made in a 36 years old woman. The pre-operative examination included genetic analysis of the succinate dehydrogenase that showed a mutation in his subunit D responsible of multiple paraganglioma at slow growth. Subsequently a thoraco-abdominal CT and indium111 octreotide body scan were performed and another paraganglioma was detected in the anterior mediastinum. CBT was surgically removed; differently the thoracic lesion due to his benign genetic profile was not treated. During a 3-years follow-up the thoracic paraganglioma as expected, didn't increase. Genetic analysis of succinate dehydrogenase, should be performed in the management of CBT.

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KW - Paraganglioma

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