Role of the non-receptor tyrosine kinase Fes in cancer

F. Condorelli, E. Stec-Martyna, J. Zaborowska, L. Felli, I. Gemmi, M. Ponassi, C. Rosano

Research output: Contribution to journalArticlepeer-review

Abstract

Non receptor protein tyrosine kinases are targets in the treatment of a number of diseases. This review focuses on the role of Fes tyrosine kinase and on the design of inhibitors of this protein. Fes and its homologously related protein Fer are the only two members of a distinct class of non receptor tyrosine kinases and they seem to play a role in cytoskeletal rearrangements and inside-out signalling associated with receptor-ligand, cell-matrix and cell-cell interactions. The knowledge of the three dimensional structure of this protein, in fact, has informed drug design, while at the same time it has helped to shed some light on the molecular mechanism at the basis of kinase activation and functions.

Original languageEnglish
Pages (from-to)2913-2920
Number of pages8
JournalCurrent Medicinal Chemistry
Volume18
Issue number19
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Fes kinase
  • Non receptor tyrosine kinase
  • Protein crystallography
  • Protein structure
  • Structure based drug design

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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