Ruolo del gene p53 nel pathway apoptotico: Implicazioni cliniche

Translated title of the contribution: Role of the p53 gene in the apoptotic pathway: Clinical implications

E. Ricevuto, K. Cannita, C. Z. Di Rocco, P. Marchetti, C. Ficorella

Research output: Contribution to journalArticlepeer-review

Abstract

The p53 tumor suppressor gene plays a central role in multiple processes such as cell cycle control, DNA repair and programmed cell death. Functional inactivation of p53 gene by structural alterations, interaction with viral products or by endogenous cellular mechanisms represents a critical step toward the development of human malignancies. P53 mutations occur in almost half of all cancer patients and in some tumor type these mutations are associated with worse prognosis and with chemio/radioresistance, which may be due to inability to trigger programmed cell death. The evolving knowledge of apoptotic pathways involving p53 will improve the development of novel approaches to treat cancer patients according to the p53 functional status.

Translated title of the contributionRole of the p53 gene in the apoptotic pathway: Clinical implications
Original languageItalian
Pages (from-to)84-87
Number of pages4
JournalEOS Rivista di Immunologia ed Immunofarmacologia
Volume19
Issue number3-4
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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