Role of the thalamic reticular nucleus in the generation of rhythmic thalamo-cortical activities subserving spike and waves

G. Avanzini, M. De Curtis, C. Marescaux, F. Panzica, R. Spreafico, M. Vergnes

Research output: Contribution to journalArticle

Abstract

The role of the reticular thalamic nucleus (RTN) in pacing rhythmic cortical activities subserving spike-waves (SW) discharges has been investigated in rats. Intracellular recordings from thalamic slices in vitro demonstrated that RTN neurons from control animals possess a set of Ca2+/K+ membrane conductances which enable them to produce rhythmic oscillatory activities. In vivo, studies of Ca2+-conductance blockade by intrathalamic injections of Cd2+ were performed on 24 callosotomized Wistar rats displaying spontaneous SW discharges, bred at the Centre de Neurochimie, Strasbourg. A significant decrement in ipsilateral SW activity was consistently observed in all RTN-injected animals 40 min after Cd2+ injection. By contrast, animals which received Cd2+ injection into the ventroposterior complex (VP) showed only small changes in ipsilateral SW. It is concluded that Ca2+-dependent oscillatory properties of the RTN are critical for the expression of genetically determined SW discharges in the Wistar model.

Original languageEnglish
Pages (from-to)85-95
Number of pages11
JournalJournal of Neural Transmission, Supplement
Issue number35
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Neuroscience(all)

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