Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells

C. Riccardi; G. Migliorati; A. Giampietri; L. Frati; B. Herberman

Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells

C. Riccardi, G. Migliorati, A. Giampietri, L. Frati, B. Herberman

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Abstract

We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1⁺, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.

Original language	English
Pages (from-to)	401-408
Number of pages	8
Journal	International Journal of Tissue Reactions
Volume	6
Issue number	5
Publication status	Published - 1984

ASJC Scopus subject areas

Physiology
Cell Biology

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abstract = "We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.",

author = "C. Riccardi and G. Migliorati and A. Giampietri and L. Frati and B. Herberman",

year = "1984",

language = "English",

volume = "6",

pages = "401--408",

journal = "International Journal of Tissue Reactions",

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T1 - Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells

AU - Riccardi, C.

AU - Migliorati, G.

AU - Giampietri, A.

AU - Frati, L.

AU - Herberman, B.

PY - 1984

Y1 - 1984

N2 - We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.

AB - We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.

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