Abstract
We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.
| Original language | English |
|---|---|
| Pages (from-to) | 401-408 |
| Number of pages | 8 |
| Journal | International Journal of Tissue Reactions |
| Volume | 6 |
| Issue number | 5 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Physiology
- Cell Biology
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Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells. / Riccardi, C.; Migliorati, G.; Giampietri, A.; Frati, L.; Herberman, B.
In: International Journal of Tissue Reactions, Vol. 6, No. 5, 1984, p. 401-408.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells
AU - Riccardi, C.
AU - Migliorati, G.
AU - Giampietri, A.
AU - Frati, L.
AU - Herberman, B.
PY - 1984
Y1 - 1984
N2 - We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.
AB - We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.
UR - http://www.scopus.com/inward/record.url?scp=0021676196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021676196&partnerID=8YFLogxK
M3 - Article
C2 - 6335142
AN - SCOPUS:0021676196
VL - 6
SP - 401
EP - 408
JO - International Journal of Tissue Reactions
JF - International Journal of Tissue Reactions
SN - 0250-0868
IS - 5
ER -