Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells

C. Riccardi, G. Migliorati, A. Giampietri, L. Frati, B. Herberman

Research output: Contribution to journalArticlepeer-review

Abstract

We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalInternational Journal of Tissue Reactions
Volume6
Issue number5
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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