Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells

C. Riccardi, G. Migliorati, A. Giampietri, L. Frati, B. Herberman

Research output: Contribution to journalArticle

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Abstract

We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalInternational Journal of Tissue Reactions
Volume6
Issue number5
Publication statusPublished - 1984

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Natural Killer Cells
Thymus Gland
Interleukin-2
Growth
Isoantigens
Population

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells. / Riccardi, C.; Migliorati, G.; Giampietri, A.; Frati, L.; Herberman, B.

In: International Journal of Tissue Reactions, Vol. 6, No. 5, 1984, p. 401-408.

Research output: Contribution to journalArticle

Riccardi, C. ; Migliorati, G. ; Giampietri, A. ; Frati, L. ; Herberman, B. / Role of the thymus in the control of growth and differentiation of TCGF-sensitive natural killer (NK) cells. In: International Journal of Tissue Reactions. 1984 ; Vol. 6, No. 5. pp. 401-408.
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