Role of thyroglobulin measurement in fine-needle aspiration biopsies of cervical lymph nodes in patients with differentiated thyroid cancer

Andrea Frasoldati, Elena Toschi, Michele Zini, Marcella Flora, Angelo Caroggio, Claudio Dotti, Roberto Valcavi

Research output: Contribution to journalArticle

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Abstract

The identification of metastatic neck lymph nodes in patients awaiting surgery for differentiated thyroid tumor permits their excision during thyroidectomy. In order to detect thyroid cancer lymphatic metastasis before surgery, we measured thyroglobulin (tg) in the needle wash-out of fine- needle aspiration biopsy (fnab). Ultrasound-guided Fnab on enlarged neck nodes was performed in 23 patients awaiting surgery for differentiated thyroid tumor (n = 33 lymph nodes), 47 patients previously thyroidectomized for thyroid tumor (n = 89 lymph nodes), and 60 patients without thyroid disease (n = 94 lymph nodes). Immediately after aspiration biopsy, the needle was rinsed with 1 ml of normal saline solution and Tg levels were measured on the needle wash-out (fnabtg). Fnab-tg levels were markedly elevated in metastatic lymph nodes both in patients awaiting thyroidectomy (metastatic vs. negative lymph nodes, mean ± Sem, 16,593 ± 7,050 ng/ml vs. 4.91 ± 1.61 ng/mL; p <0.001) and in thyroidectomized patients (11,541 ± 7,283 ng/mL vs. 0.45 ± 0.07 ng/mL; p <0.001). FNAB-Tg sensitivity, evaluated through histological examination in 69 lymph nodes, was 84.0%. The combination of cytology plus FNAB-Tg increased FNAB sensitivity from 76% to 92.0%. In conclusion, FNAB-Tg measurement is a useful technique for early diagnosis of lymph node metastasis originating from differentiated thyroid cancer.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalThyroid
Volume9
Issue number2
Publication statusPublished - Feb 1999

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Thyroglobulin
Fine Needle Biopsy
Thyroid Neoplasms
Lymph Nodes
Needles
Thyroid Gland
Thyroidectomy
Neck
Lymphatic Metastasis
Neoplasms
Thyroid Diseases
Needle Biopsy
Sodium Chloride
Cell Biology
Early Diagnosis
Neoplasm Metastasis

ASJC Scopus subject areas

  • Endocrinology

Cite this

Role of thyroglobulin measurement in fine-needle aspiration biopsies of cervical lymph nodes in patients with differentiated thyroid cancer. / Frasoldati, Andrea; Toschi, Elena; Zini, Michele; Flora, Marcella; Caroggio, Angelo; Dotti, Claudio; Valcavi, Roberto.

In: Thyroid, Vol. 9, No. 2, 02.1999, p. 105-111.

Research output: Contribution to journalArticle

Frasoldati, A, Toschi, E, Zini, M, Flora, M, Caroggio, A, Dotti, C & Valcavi, R 1999, 'Role of thyroglobulin measurement in fine-needle aspiration biopsies of cervical lymph nodes in patients with differentiated thyroid cancer', Thyroid, vol. 9, no. 2, pp. 105-111.
Frasoldati, Andrea ; Toschi, Elena ; Zini, Michele ; Flora, Marcella ; Caroggio, Angelo ; Dotti, Claudio ; Valcavi, Roberto. / Role of thyroglobulin measurement in fine-needle aspiration biopsies of cervical lymph nodes in patients with differentiated thyroid cancer. In: Thyroid. 1999 ; Vol. 9, No. 2. pp. 105-111.
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