Role of TNF-α but not NGF in murine hyperalgesia induced by parasitic infection

Luigi Aloe, Rolando Moroni, Francesco Angelucci, Marco Fiore

Research output: Contribution to journalArticlepeer-review

Abstract

Using adult mice infected with the trematode Schistosoma mansoni, we observed that this infection induces both thermal hyperalgesia and an increase in the levels of nerve growth factor in the paws. To explore the mechanism involved in peripheral hypersensitivity during chronic infection, mice were infected with 60 cercariae of S. mansoni and injected 17 weeks later with nerve growth factor anti-nerve growth factor or with other molecules known to be associated with hyperalgesic processes. The results of these studies showed that antibodies against tumor necrosis factor-α, but not against nerve growth factor, reduce thermal sensitivity in schistosome infected mice, suggesting that this cytokine but not NGF plays a crucial role in schistosome-induced thermal hyperalgesia. Treatments with anti-inflammatory drugs support this hypothesis.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalPsychopharmacology
Volume134
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • Hyperalgesia
  • Mice
  • NGF
  • Schistosoma mansoni
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology

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