Role of troponin in COVID-19 pandemic: A review of literature

A. Piccioni, M. Brigida, V. Loria, C. Zanza, Y. Longhitano, R. Zaccaria, S. Racco, A. Gasbarrini, V. Ojetti, F. Franceschi, M. Candelli

Research output: Contribution to journalReview articlepeer-review

Abstract

Acute SARS-CoV-2 respiratory disease is an infectious respiratory disease caused by the virus SARS-CoV-2 belonging to the coronaviridae family. A pandemic is still present as of May 2020. In addition to causing pneumonia, SARS-CoV-2 may induce a direct damage to the heart, causing myocarditis, with significant impairment of cardiac contractility, and/or pericarditis. Elderly patients and those with cardiovascular risk factors, such as hypertension and diabetes mellitus, are at increased risk of heart complications from COVID-19. In this review, we focused on the correlation between COVID-19 infection and the high sensitivity troponin T and I, and their significance in the development of myocarditis. Data emerging from the studies so far conducted indicate that a high value of high-sensitivity troponin represents a negative prognostic indicator when associated with heart damage on an infectious-inflammatory basis (i.e. myopericarditis). We should identify a safe and clear diagnostic algorithm, possibly combining patient clinical history, troponin levels and cardiac ultrasound findings that could help us in the prediction of myopericarditis.

Original languageEnglish
Pages (from-to)10293-10300
Number of pages8
JournalEuropean Review for Medical and Pharmacological Sciences
Volume24
Issue number19
DOIs
Publication statusPublished - 2020

Keywords

  • COVID-19
  • Emergency Department
  • Myocarditis
  • Pandemic
  • Pericarditis
  • Troponin

ASJC Scopus subject areas

  • Pharmacology (medical)

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