Role of Tumor-Associated Macrophages (TAM) in Cancer Related Inflammation

Antonio Sica, Chiara Porta

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationTumor Microenvironment
PublisherJohn Wiley and Sons
Number of pages22
ISBN (Print)9780470749968
Publication statusPublished - Aug 31 2010


  • Changes in iron (Fe) metabolism - M1-M2 macrophage polarization
  • M2 signature for cancer progression
  • Macrophages as key orchestrators - of cancer-related inflammation
  • Macrophages, of innate defense mechanisms - promoting specific immunity, T-cell recruitment and activation
  • Macrophages, released from bone marrow in blood stream - as immature monocytes
  • Molecular basis of TAM-mediated immunosuppression - and T-cell activation inhibition
  • Molecular determinants of TAM functions
  • Murine tumor models - CSF-1 in TAM-mediated angiogenesis
  • Polarized inflammation, and different roles - in tumor progression
  • Role of tumor-associated macrophages (TAM) - in cancer related inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this